TY - JOUR
TI - Non-rapid eye movement sleep instability in mild cognitive impairment: a
pilot study
AU - Maestri, Michelangelo
AU - Carnicelli, Luca
AU - Tognoni, Gloria
AU - Di
AU - Coscio, Elisa
AU - Giorgi, Filippo Sean
AU - Volpi, Leda
AU - Economou,
AU - Nicholas-Tiberio
AU - Ktonas, Periklis
AU - Ferri, Raffaele and
AU - Bonuccelli, Ubaldo
AU - Bonanni, Enrica
JO - Sleep Medicine
PY - 2015
VL - 16
TODO - 9
SP - 1139-1145
PB - ELSEVIER SCIENCE BV
SN - 1389-9457
TODO - 10.1016/j.sleep.2015.04.027
TODO - Mild cognitive impairment; Cyclic alternating pattern; Alzheimer's
disease; NREM sleep instability; Neurodegeneration; Nap
TODO - Objective: Polysomnographic (PSG) studies in mild cognitive impairment
(MCI) are not conclusive and are limited only to conventional sleep
parameters. The aim of our study was to evaluate sleep architecture and
cyclic alternating pattern (CAP) parameters in subjects with MCI, and to
assess their eventual correlation with cognition.
Methods: Eleven subjects with MCI (mean age 68.5 +/- 7.0 years), 11
patients with mild probable Alzheimer's disease (AD; mean age 72.7 +/-
5.9 years), referred to the Outpatient Cognitive Disorders Clinic, and
11 cognitively intact healthy elderly individuals (mean age 69.2 +/-
12.6 years) underwent ambulatory PSG for the evaluation of nocturnal
sleep architecture and CAP parameters.
Results: Rapid eye movement sleep, CAP rate, and CAP slow components (A1
index) were decreased in MCI subjects and to a greater extent in AD
patients, compared to cognitively intact controls. AD showed also
decreased slow wave sleep (SWS) relative to healthy elderly individuals.
MCI nappers showed decreased nocturnal SWS and A1 subtypes compared to
non-nappers. Several correlations between sleep variables and
neuropsychological tests were found.
Conclusions: MCI and AD subjects showed a decreased sleep instability
correlated with their cognitive decline. Such a decrease may be
considered as a potential biomarker of underlying neurodegeneration. (C)
2015 Elsevier B.V. All rights reserved.
ER -