TY - JOUR
TI - Pre-diagnostic polyphenol intake and breast cancer survival: the
European Prospective Investigation into Cancer and Nutrition (EPIC)
cohort
AU - Kyro, Cecilie
AU - Zamora-Ros, Raul
AU - Scalbert, Augustin and
AU - Tjonneland, Anne
AU - Dossus, Laure
AU - Johansen, Christoffer and
AU - Bidstrup, Pernille Envold
AU - Weiderpass, Elisabete
AU - Christensen,
AU - Jane
AU - Ward, Heather
AU - Aune, Dagfinn
AU - Riboli, Elio
AU - His,
AU - Mathilde
AU - Clavel-Chapelon, Francoise
AU - Baglietto, Laura
AU - Katzke,
AU - Verena
AU - Kuehn, Tilman
AU - Boeing, Heiner
AU - Floegel, Anna and
AU - Overvad, Kim
AU - Lasheras, Cristina
AU - Travier, Noemie
AU - Sanchez,
AU - Maria-Jose
AU - Amiano, Pilar
AU - Chirlaque, Maria-Dolores
AU - Ardanaz,
AU - Eva
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Perez-Cornago, Aurora and
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Vasilopoulou, Effie and
AU - Masala, Giovanna
AU - Grioni, Sara
AU - Berrino, Franco
AU - Tumino,
AU - Rosario
AU - Sacerdote, Carlotta
AU - Mattiello, Amalia and
AU - Bueno-de-Mesquita, H. B(as).
AU - Peeters, Petra H.
AU - van Gils, Carla
AU - and Borgquist, Signe
AU - Butt, Salma
AU - Zeleniuch-Jacquotte, Anne and
AU - Sund, Malin
AU - Hjartaker, Anette
AU - Skeie, Guri
AU - Olsen, Anja and
AU - Romieu, Isabelle
JO - Breast Cancer Research and Treatment
PY - 2015
VL - 154
TODO - 2
SP - 389-401
PB - Springer-Verlag
SN - 0167-6806, 1573-7217
TODO - 10.1007/s10549-015-3595-9
TODO - Breast cancer; Survivorship; Polyphenols; Phytoestrogens; Lignans
TODO - The aim was to investigate the association between pre-diagnostic
intakes of polyphenol classes (flavonoids, lignans, phenolic acids,
stilbenes, and other polyphenols) in relation to breast cancer survival
(all-cause and breast cancer-specific mortality). We used data from the
European Prospective Investigation into Cancer and Nutrition cohort.
Pre-diagnostic usual diet was assessed using dietary questionnaires, and
polyphenol intakes were estimated using the Phenol-Explorer database. We
followed 11,782 breast cancer cases from time of diagnosis until death,
end of follow-up or last day of contact. During a median of 6 years,
1482 women died (753 of breast cancer). We related polyphenol intake to
all-cause and breast cancer-specific mortality using Cox proportional
hazard models with time since diagnosis as underlying time and strata
for age and country. Among postmenopausal women, an intake of lignans in
the highest versus lowest quartile was related to a 28 % lower risk of
dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72,
95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive
association between lignan intake and all-cause mortality was found
(adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03;
2.57). We found no association for other polyphenol classes. Intake of
lignans before breast cancer diagnosis may be related to improved
survival among postmenopausal women, but may on the contrary worsen the
survival for premenopausal women. This suggests that the role of
phytoestrogens in breast cancer survival is complex and may be dependent
of menopausal status.
ER -