TY - JOUR
TI - TSH-secreting pituitary adenomas treated by gamma knife radiosurgery:
our case experience and a review of the literature
AU - Mouslech, Zadalla
AU - Somali, Maria
AU - Sakali, Anastasia Konstantina
AU - and Savopoulos, Christos
AU - Mastorakos, George
AU - Hatzitolios,
AU - Apostolos I.
JO - HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
PY - 2016
VL - 15
TODO - 1
SP - 122-128
PB - SPRINGER INTERNATIONAL PUBLISHING AG
SN - null
TODO - 10.1007/BF03401412
TODO - Thyrotropin-secreting pituitary adenoma; Hyperthyroidism; Long-acting
somatostatin analogs; Transsphenoidal adenomectomy; Gamma knife
radiosurgery; Long-term remission
TODO - A 43-year-old woman, previously misdiagnosed as having primary
hyperthyroidism and treated with antithyroid drugs, presented to us with
overt hyperthyroidism, high levels of thyroid hormones and elevated
thyroid-stimulating hormone (TSH). Magnetic resonance imaging (MRI)
revealed a pituitary microadenoma extending suprasellarly. The patient
responded favorably to initial treatment with somatostatin analogs for 2
years but due to the escape phenomenon, TSH levels escalated and
hyperthyroidism relapsed. Transsphenoidal adenomectomy was applied but
recurrence was again observed due to incomplete tumor removal. Gamma
knife radiosurgery was finally employed 5.5 years ago, resulting in
complete disease remission without evidence of long-term complications
to date. Thyrotropin-secreting adenomas (TSHomas) are rare with an
estimated prevalence of about one case per million. We retrieved from
the literature 14 cases of TSHomas treated by gamma knife radiosurgery
and compared the outcomes. Our results demonstrate the efficacy and
safety of gamma knife radiosurgery for achieving remission in most of
the cases, suggesting validation of this technique as an effective
treatment option for the management of recurrent TSHomas.
ER -