TY - JOUR
TI - Increased Maternal Serum Interleukin-6 Concentrations at 11 to 14 Weeks
of Gestation in Low Risk Pregnancies Complicated with Gestational
Diabetes Mellitus: Development of a Prediction Model
AU - Hassiakos, D.
AU - Eleftheriades, M.
AU - Papastefanou, I. and
AU - Lambrinoudaki, I.
AU - Kappou, D.
AU - Lavranos, D.
AU - Akalestos, A. and
AU - Aravantinos, L.
AU - Pervanidou, P.
AU - Chrousos, G.
JO - Hormone and Metabolic Research
PY - 2016
VL - 48
TODO - 1
SP - 35-41
PB - Georg Thieme Verlag KG
SN - 0018-5043, 1439-4286
TODO - 10.1055/s-0034-1395659
TODO - gestational diabetes mellitus cytokine; prediction model; IL-6; first
trimester; screening
TODO - The aim of the study was to examine interleukin-6 (IL-6) maternal serum
concentration at 11 to 14 gestational weeks in normal pregnancies and
pregnancies complicated by gestational diabetes mellitus (GDM) and to
create first trimester prediction models for GDM. Case-control study
conducted in a Fetal Medicine Unit. Study population included 40 GDM
cases and 94 controls. Maternal characteristics, first trimester
ultrasound markers, biochemical indices, and IL-6 levels were used for
our analysis. IL-6 was related to maternal weight among the maternal
characteristics, (R-2 = 0.0679, p = 0.01). IL-6 was increased (p =
0.001) in the GDM group (median = 2 pg/ml) compared to the control group
(median = 1.5 pg/ml) even after adjustment for maternal weight. IL-6 was
inversely related to birth weight adjusted for gestational age at
delivery (r = -0.3382, p < 0.001) and glucose levels at oral glucose
test. Maternal weight and age were the only predictors of GDM among the
maternal characteristics [Detection Rate (DR) = 59.4 %; for 25 %
False Positive Rate (FPR); Area Under the Curve (AUC) = 0.7291; Model
R-2 = 0.1096, p < 0.001]. IL-6 alone was a significant predictor of GDM
(DR = 51.3 %; for 25 % FPR; AUC = 0.6731; Model R-2 = 0.0616, p <
0.001). Combination of maternal characteristics with IL-6 yielded an
improved prediction (DR = 67.5 %; for 25 % FPR; AUC = 0.7586; Model
R-2 = 0.1521, p < 0.001). IL-6 concentrations are increased at 11-14
weeks in pregnancies with GDM. Combination of maternal characteristics
and maternal serum IL-6 levels may provide effective first trimester
screening for GDM.
ER -