TY - JOUR
TI - The effect of minimal dietary changes with raisins in NAFLD patients
with non-significant fibrosis: a randomized controlled intervention
AU - Kaliora, Andriana C.
AU - Kokkinos, Alexander
AU - Diolintzi, Anastacia
AU - and Stoupaki, Maria
AU - Gioxari, Aristea
AU - Kanellos, Panagiotis T. and
AU - Dedoussis, George V. Z.
AU - Vlachogiannakos, Jiannis
AU - Revenas,
AU - Constantinos
AU - Ladas, Spiros D.
AU - Karathanos, Vaios T.
JO - Food & Function
PY - 2016
VL - 7
TODO - 11
SP - 4533-4544
PB - ROYAL SOC CHEMISTRY
SN - 2042-6496, 2042-650X
TODO - 10.1039/c6fo01040g
TODO - null
TODO - Aiming at investigating the potential effect of minimal dietary changes
in NAFLD patients with nonsignificant fibrosis, 55 patients with NAFLD
were enrolled in a randomized controlled clinical trial. Patients were
assigned into two isocaloric dietary treatment groups for 24 weeks: (a)
nutritional counseling (Control arm, N = 27), (b) nutritional counseling
with currants included (two fruit servings, 36 g per day), substituting
snacks of similar caloric content (Currant arm, N = 28). Clinical tests,
anthropometrics, inflammatory and oxidative stress markers were
conducted pre-and post-intervention. A total of 50 patients completed
the trial. Significant differences between the two arms
post-intervention were observed in fasting glucose and in IL-6 levels,
these being significantly decreased only in Currant patients. Body
weight, BMI, HbA(1c), CRP and EUS values decreased in both arms,
differences being insignificant between the two arms post-intervention.
Participants in the Currant arm had significantly reduced total body
fat, WC and trunk fat. Ultrasound scanning improved significantly in
patients snacking currants daily. Also, volunteers enrolled in the
Currant arm showed a reduced intake of saturated fatty acids. Because BW
regulation has been officially recognised as a treatment approach in
NAFLD an additional analysis was repeated in patients adhering to this.
Post-intervention, the decrease in IL-6 and in fasting glucose was
significantly higher in Currant patients who lost BW compared to their
counterparts in the Control arm. Conclusively, minimal modifications in
snacking choices, such as the inclusion of dried grapes in diet, are
beneficial in NAFLD patients with non-significant fibrosis.
ER -