TY - JOUR
TI - STAT3-Ser/Hes3 Signaling: A New Molecular Component of the
Neuroendocrine System?
AU - Nikolakopoulou, P.
AU - Poser, S. W.
AU - Masjkur, J.
AU - de Celis, M.
AU - Fernandez Rubin
AU - Toutouna, L.
AU - Andoniadou, C. L.
AU - McKay, R. D.
AU - and Chrousos, G.
AU - Ehrhart-Bornstein, M.
AU - Bornstein, S. R. and
AU - Androutsellis-Theotokis, A.
JO - Hormone and Metabolic Research
PY - 2016
VL - 48
TODO - 2
SP - 77-82
PB - Georg Thieme Verlag KG
SN - 0018-5043, 1439-4286
TODO - 10.1055/s-0041-111699
TODO - STAT3; Hes3; stem cells
TODO - The endocrine system involves communication among different tissues in
distinct organs, including the pancreas and components of the
Hypothalamic-Pituitary-Adrenal Axis. The molecular mechanisms underlying
these complex interactions are a subject of intense study as they may
hold clues for the progression and treatment of a variety of metabolic
and degenerative diseases. A plethora of signaling pathways, activated
by hormones and other endocrine factors have been implicated in this
communication. Recent advances in the stem cell field introduce a new
level of complexity: adult progenitor cells appear to utilize distinct
signaling pathways than the more mature cells in the tissue they
co-reside. It is therefore important to elucidate the signal
transduction requirements of adult progenitor cells in addition to those
of mature cells. Recent evidence suggests that a common non-canonical
signaling pathway regulates adult progenitors in several different
tissues, rendering it as a potentially valuable starting point to
explore their biology. The STAT3-Ser/Hes3 Signaling Axis was first
identified as a major regulator of neural stem cells and, subsequently,
cancer stem cells. In the endocrine/neuroendocrine system, this pathway
operates on several levels, regulating other types of plastic cells: (a)
it regulates pancreatic islet cell function and insulin release; (b)
insulin in turn activates the pathway in broadly distributed neural
progenitors and possibly also hypothalamic tanycytes, cells with
important roles in the control of the adrenal gland; (c) adrenal
progenitors themselves operate this pathway. The STAT3-Ser/Hes3
Signaling Axis therefore deserves additional research in the context of
endocrinology.
ER -