TY - JOUR
TI - Low frequency of cigarette smoking and the risk of head and neck cancer
in the INHANCE consortium pooled analysis
AU - Berthiller, Julien
AU - Straif, Kurt
AU - Agudo, Antonio
AU - Ahrens,
AU - Wolfgang
AU - dos Santos, Alexandre Bezerra
AU - Boccia, Stefania and
AU - Cadoni, Gabriella
AU - Canova, Cristina
AU - Castellsague, Xavier and
AU - Chen, Chu
AU - Conway, David
AU - Curado, Maria Paula
AU - Dal Maso,
AU - Luigino
AU - Daudt, Alexander W.
AU - Fabianova, Eleonora
AU - Fernandez,
AU - Leticia
AU - Franceschi, Silvia
AU - Fukuyama, Erica E.
AU - Hayes, Richard
AU - B.
AU - Healy, Claire
AU - Herrero, Rolando
AU - Holcatova, Ivana and
AU - Kelsey, Karl
AU - Kjaerheim, Kristina
AU - Koifman, Sergio
AU - Lagiou,
AU - Pagona
AU - La Vecchia, Carlo
AU - Lazarus, Philip
AU - Levi, Fabio and
AU - Lissowska, Jolanta
AU - Macfarlane, Tatiana
AU - Mates, Dana
AU - McClean,
AU - Michael
AU - Menezes, Ana
AU - Merletti, Franco
AU - Morgenstern, Hal and
AU - Muscat, Joshua
AU - Olshan, Andrew F.
AU - Purdue, Mark
AU - Ramroth,
AU - Heribert
AU - Rudnai, Peter
AU - Schwartz, Stephen M.
AU - Serraino, Diego
AU - and Shangina, Oxana
AU - Smith, Elaine
AU - Sturgis, Erich M. and
AU - Szeszenia-Dabrowska, Neonila
AU - Thomson, Peter
AU - Vaughan, Thomas L.
AU - and Vilensky, Marta
AU - Wei, Qingyi
AU - Winn, Deborah M. and
AU - Wunsch-Filho, Victor
AU - Zhang, Zuo-Feng
AU - Znaor, Ariana
AU - Ferro,
AU - Gilles
AU - Brennan, Paul
AU - Boffetta, Paolo
AU - Hashibe, Mia
AU - Lee,
AU - Yuan-Chin Amy
JO - International Journal of Epidemiology
PY - 2016
VL - 45
TODO - 3
SP - 835-845
PB - Oxford University Press
SN - 0300-5771, 1464-3685
TODO - 10.1093/ije/dyv146
TODO - Head and neck cancer; low frequency cigarette smoking; risk factors;
pooled analysis
TODO - Background: Cigarette smoking is a major risk factor for head and neck
cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes
per day) has not been extensively investigated in fine categories or
among never alcohol drinkers.
Methods: We conducted a pooled analysis of individual participant data
from 23 independent case-control studies including 19 660 HNC cases and
25 566 controls. After exclusion of subjects using other tobacco
products including cigars, pipes, snuffed or chewed tobacco and straw
cigarettes (tobacco product used in Brazil), as well as subjects smoking
more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were
included in the analysis. The lifetime average frequency of cigarette
consumption was categorized as follows: never cigarette users, >0-3,
>3-5, >5-10 cigarettes per day.
Results: Smoking >0-3 cigarettes per day was associated with a 50%
increased risk of HNC in the study population [ odds ratio (OR) =
1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5
cigarettes per day was associated in each subgroup from OR = 2.01 (95%
CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI:
2.01, 3.74) among women and in each cancer site, particularly laryngeal
cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased
risk of HNC for low smoking frequency was not found among smokers with
smoking duration shorter than 20 years.
Conclusion: Our results suggest a public health message that low
frequency of cigarette consumption contributes to the development of
HNC. However, smoking duration seems to play at least an equal or a
stronger role in the development of HNC.
ER -