TY - JOUR
TI - Health resource utilization associated with skeletal-related events:
results from a retrospective European study
AU - Body, Jean-Jacques
AU - Pereira, Joao
AU - Sleeboom, Harm
AU - Maniadakis,
AU - Nikos
AU - Terpos, Evangelos
AU - Acklin, Yves Pascal
AU - Finek, Jindrich
AU - and Gunther, Oliver
AU - Hechmati, Guy
AU - Mossman, Tony
AU - Costa, Luis
AU - and Rogowski, Wojciech
AU - Nahi, Hareth
AU - von Moos, Roger
JO - The European Journal of Health Economics
PY - 2016
VL - 17
TODO - 6
SP - 711-721
PB - Springer-Verlag
SN - 1618-7598, 1618-7601
TODO - 10.1007/s10198-015-0716-7
TODO - Health resource utilization (HRU); Skeletalrelated event (SRE); Bone
metastases; Breast cancer; Prostate cancer; Lung cancer
TODO - Background Bone complications, also known as skeletal-related events
(SREs), are common in patients with bone metastases secondary to
advanced cancers.
Objective To provide a detailed estimate of the health resource
utilization (HRU) burden associated with SREs across eight European
countries.
Methods Eligible patients from centers in Austria, the Czech Republic,
Finland, Greece, Poland, Portugal, Sweden, and Switzerland with bone
metastases or lesions secondary to breast cancer, prostate, or lung
cancer or multiple myeloma who had experienced at least one SRE (defined
as radiation to bone, long-bone pathologic fracture, other bone
pathologic fracture, surgery to bone or spinal cord compression) were
entered into this study. HRU data were extracted retrospectively from
the patients' charts from 3.5 months before the index SRE until 3 months
after the index SRE (defined as an SRE preceded by an SRE-free period of
at least 6.5 months).
Results Overall, the mean number of inpatient stays per SRE increased
from baseline by approximately 0.5-1.5 stays, with increases in the
total duration of inpatient stays of approximately 6-37 days per event.
All SREs were associated with substantial increases from baseline in the
frequency of procedures and the number of outpatient and day-care
visits.
Conclusions SREs are associated with substantial HRU owing to
considerable increases in the number and duration of inpatient stays,
and in the number of procedures, outpatient visits, and day-care visits.
These data collectively provide a valuable summary of the real-world SRE
burden on European healthcare systems.
ER -