TY - JOUR
TI - Modeling and administration scheduling of fractional-order
pharmacokinetic systems
AU - Herceg, Domagoj
AU - Ntouskas, Sotiris
AU - Sopasakis, Pantelis and
AU - Dokoumetzidis, Aris
AU - Macheras, Panos
AU - Sarimveis, Haralambos and
AU - Patrinos, Panagiotis
JO - IFAC-PapersOnLine
PY - 2017
VL - 50
TODO - 1
SP - 9742-9747
PB - Elsevier
SN - 2405-8963
TODO - 10.1016/j.ifacol.2017.08.2178
TODO - Fractional-order systems; Pharmacokinetics; Drug administration
TODO - Fractional-order dynamical systems were recently introduced in the field
of pharmacokinetics where they proved powerful tools for modeling the
absorption, disposition, distribution and excretion of drugs which are
liable to anomalous diffusion, deep tissue trapping and other nonlinear
phenomena. In this paper we present several ways to simulate such
fractional order pharmacokinetic models and we evaluate their accuracy
and complexity on a fractional order pharmacokinetic model of
Amiodarone, an anti-arrhythmic drug. We then propose an optimal
administration scheduling scheme and evaluate it on a population of
patients. (C) 2017, IFAC (International Federation of Automatic Control)
Hosting by Elsevier Ltd. All rights reserved.
ER -