TY - JOUR
TI - The-174 G > C Interleukin-6 Gene Polymorphism is Associated with
Angiographic Progression of Coronary Artery Disease over a 4-Year Period
AU - Toutouzas, Konstantinos
AU - Klettas, Dimitrios and
AU - Anousakis-Vlachochristou, Nikolaos
AU - Melidis, Konstantinos and
AU - Azilazian, Zeta
AU - Asimomiti, Maria
AU - Karanasos, Antonios
AU - Spanos,
AU - Anastasios
AU - Tsiamis, Eleftherios
AU - Nihoyannopoulos, Petros and
AU - Tousoulis, Dimitris
JO - Ελληνική καρδιολογική επιθεώρηση
PY - 2017
VL - 58
TODO - 1
SP - 80-86
PB - HELLENIC CARDIOLOGICAL SOC
SN - 1011-7970
TODO - 10.1016/j.hjc.2017.02.002
TODO - Coronary artery disease; inflammation; progression; interleukin-6; gene
polymorphisms; SNP
TODO - Background: Inflammation is a key process underlying the clinical course
of coronary artery disease (CAD). C-reactive protein (CRP) and
interleukin-6 (IL-6) contribute to its pathophysiology and act as
biomarkers. We sought to examine whether known single nucleotide
polymorphisms (SNPs) impact CAD progression, reflecting increased
inflammation.
Methods: We retrospectively evaluated coronary angiographies of patients
with established CAD who were re-investigated for stable/unstable angina
after a time interval of > 12 months. We defined progression of CAD as
the emergence of a new plaque or a >= 20 % increase of a formerly
non-significant lesion. We genotyped patients for the 1846 C > T CRP and
-174 G > C IL-6 SNPs. The probability of CAD progression among the
Mendelian randomization groups was evaluated using the Kaplane-Meier
method. Data were analyzed using a Cox model that included relevant
clinical factors.
Results: A total of 157 patients were included. The serum levels of CRP
and IL-6 differed significantly between genotypes. The genotype
frequencies of IL-6 were consistent with Hardy -Weinberg equilibrium,
whereas those for CRP were excluded from our conclusions. At 48 months,
83 patients (52.9 %) with the IL-6 C allele versus 74 (47.1 %) with
the G allele exhibited CAD progression. Patients with the IL-6 C allele
had a 52.8 % probability for progression versus 13.3 % for those with
the G allele (p=0.005). The results were confirmed by multivariate
analysis; dyslipidemia, family history, and IL-6 SNP emerged as
significant factors.
Conclusion: Patients with established CAD who carried the -174 C allele
of the IL-6 gene demonstrated an increased risk for the progression of
coronary plaques over a four-year period. Further studies will be needed
to validate these findings. (c) 2017 Hellenic Society of Cardiology.
Publishing services by Elsevier B. V.
ER -