TY - JOUR
TI - Measured Adiposity in Relation to Head and Neck Cancer Risk in the
European Prospective Investigation into Cancer and Nutrition
AU - Ward, Heather A.
AU - Wark, Petra A.
AU - Muller, David C.
AU - Steffen,
AU - Annika
AU - Johansson, Mattias
AU - Norat, Teresa
AU - Gunter, Marc J. and
AU - Overvad, Kim
AU - Dahm, Christina C.
AU - Halkjaer, Jytte
AU - Tojonneland,
AU - Anne
AU - Boutron-Ruault, Marie-Christine
AU - Fagherazzi, Guy and
AU - Mesrine, Sylvie
AU - Brennan, Paul
AU - Freisling, Heinz
AU - Li, Kuanrong
AU - and Kaaks, Rudolf
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona and
AU - Panico, Salavatore
AU - Grioni, Sara
AU - Tumino, Rosario
AU - Vineis,
AU - Paolo
AU - Palli, Domenico
AU - Peeters, Petra H. M. and
AU - Bueno-de-Mesquita, H. Bas.
AU - Weiderpass, Elisabete
AU - Agudo, Antonio
AU - and Ramon Quiros, Jose
AU - Larranaga, Nerea
AU - Ardanaz, Eva
AU - Maria
AU - Huerta, Jose
AU - Sanchez, Maria-Jose
AU - Laurell, Goran
AU - Johansson,
AU - Ingegerd
AU - Westin, Ulla
AU - Wallstrom, Peter
AU - Bradbury, Kathryn E.
AU - and Wareham, Nicholas J.
AU - Khaw, Kay-Tee
AU - Pearson, Clare and
AU - Boeing, Heiner
AU - Riboli, Elio
JO - Cancer Epidemiology, Biomarkers & Prevention
PY - 2017
VL - 26
TODO - 6
SP - 895-904
PB - AMER ASSOC CANCER RESEARCH
SN - 1055-9965, 1538-7755
TODO - 10.1158/1055-9965.EPI-16-0886
TODO - null
TODO - Background: Emerging evidence from cohort studies indicates that
adiposity is associated with greater incidence of head and neck cancer.
However, most studies have used self-reported anthropometry which is
prone to error.
Methods: Among 363,094 participants in the European Prospective
Investigation into Cancer and Nutrition study (EPIC) with measured
anthropometry, there were 837 incident cases of head and neck cancer.
Head and neck cancer risk was examined in relation to body mass index
(BMI) [lean: <22.5 kg/m(2), normal weight (reference): 22.5-24.9
kg/m(2), overweight 25-29.9 kg/m(2), obese: >= 30 kg/m(2)], waist
circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR)
using Cox proportional hazards models.
Results: Among men, a BMI <22.5 kg/m(2) was associated with higher head
and neck cancer risk [HR 1.62; 95% confidence interval (CI),
1.23-2.12)]; BMI was not associated with head and neck cancer among
women. WC and WHR were associated with greater risk of head and neck
cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02-1.15; WHR per
0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking
status, the association for WHR was present only among smokers
(P-interaction = 0.004). Among men, WC and WHR were associated with head
and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR
1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI,
1.21-1.65).
Conclusions: Central adiposity, particularly among women, may have a
stronger association with head and neck cancer risk than previously
estimated.
ER -