TY - JOUR
TI - Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of
Cardiovascular Disease An Individual Participant Data Meta-Analysis
AU - Ohkuma, Toshiaki
AU - Ninomiya, Toshiharu
AU - Tomiyama, Hirofumi and
AU - Kario, Kazuomi
AU - Hoshide, Satoshi
AU - Kita, Yoshikuni
AU - Inoguchi,
AU - Toyoshi
AU - Maeda, Yasutaka
AU - Kohara, Katsuhiko
AU - Tabara, Yasuharu
AU - and Nakamura, Motoyuki
AU - Ohkubo, Takayoshi
AU - Watada, Hirotaka and
AU - Munakata, Masanori
AU - Ohishi, Mitsuru
AU - Ito, Norihisa
AU - Nakamura,
AU - Michinari
AU - Shoji, Tetsuo
AU - Vlachopoulos, Charalambos
AU - Yamashina,
AU - Akira
AU - Collaborative Grp J-BAVEL Japan
JO - JOURNAL OF HYPERTENSION
PY - 2017
VL - 69
TODO - 6
SP - 1045+
PB - Lippincott, Williams & Wilkins
SN - -
TODO - 10.1161/HYPERTENSIONAHA.117.09097
TODO - arterial stiffness; brachial-ankle pulse wave velocity; cardiovascular
disease; individual participant data meta-analysis; risk factors
TODO - An individual participant data meta-analysis was conducted in the data
of 14 673 Japanese participants without a history of cardiovascular
disease (CVD) to examine the association of the brachial-ankle pulse
wave velocity (baPWV) with the risk of development of CVD. During the
average 6.4-year follow-up period, 687 participants died and 735
developed cardiovascular events. A higher baPWV was significantly
associated with a higher risk of CVD, even after adjustments for
conventional risk factors (P for trend <0.001). When the baPWV values
were classified into quintiles, the multivariable-adjusted hazard ratio
for CVD increased significantly as the baPWV quintile increased. The
hazard ratio in the subjects with baPWV values in quintile 5 versus that
in those with the values in quintile 1 was 3.50 (2.14-5.74; P<0.001).
Every 1 SD increase of the baPWV was associated with a 1.19-fold
(1.10-1.29; P<0.001) increase in the risk of CVD. Moreover, addition of
baPWV to a model incorporating the Framingham risk score significantly
increased the C statistics from 0.8026 to 0.8131 (P<0.001) and also
improved the category-free net reclassification (0.247; P<0.001). The
present meta-analysis clearly established baPWV as an independent
predictor of the risk of development of CVD in Japanese subjects without
preexisting CVD. Thus, measurement of the baPWV could enhance the
efficacy of prediction of the risk of development of CVD over that of
the Framingham risk score, which is based on the traditional
cardiovascular risk factors.
ER -