TY - JOUR
TI - Impact of an optical coherence tomography guided approach in acute
coronary syndromes: A propensity matched analysis from the international
FORMIDABLE-CARDIOGROUP IV and USZ registry
AU - Iannaccone, Mario
AU - D'Ascenzo, Fabrizio
AU - Frangieh, Antonio H. and
AU - Niccoli, Giampaolo
AU - Ugo, Fabrizio
AU - Boccuzzi, Giacomo
AU - Bertaina,
AU - Maurizio
AU - Mancone, Massimo
AU - Montefusco, Antonio
AU - Amabile,
AU - Nicolas
AU - Sardella, Gennaro
AU - Motreff, Pascal
AU - Toutouzas,
AU - Konstantinos
AU - Colombo, Francesco
AU - Garbo, Roberto and
AU - Biondi-Zoccai, Giuseppe
AU - Tamburino, Corrado
AU - Omede, Pierluigi and
AU - Moretti, Claudio
AU - D'amico, Maurizio
AU - Souteyrand, Geraud and
AU - Meieir, Pascal
AU - Luescher, Thomas F.
AU - Gaita, Fiorenzo
AU - Templin,
AU - Christian
JO - Catheterization and Cardiovascular Interventions (Formerly Catheterization and Cardiovascular Diagnosis)
PY - 2017
VL - 90
TODO - 2
SP - E46-E52
PB - Wiley
SN - 1522-1946, 1522-726X
TODO - 10.1002/ccd.26880
TODO - optical coherence tomography; acute coronary syndrome; drug eluting
stent
TODO - Aim. To determine the potential clinical impact of OCT (Optical
Coherence Tomography) during primary percutaneous coronary intervention
in patients presenting with ACS (Acute Coronary Syndrome). Methods and
Results. FORMIDABLE is a multicentre retrospective registry enrolling
all patients presenting with ACS and treated with an OCT-guided
approach, while the USZ registry enrolled patients treated with a
standard angiography guided approach. Multivariate adjustment was
performed via a propensity score matching. The number stents useds was
the primary outcome, while the incidence of MACE (a composite of death,
myocardial infarction, target vessel revascularization, and stent
thrombosis) was the secondary endpoint. A total of 285 patients
OCT-guided and 1,547 angiography guided patients were enrolled,
resulting in 270 for each cohort after propensity score with matching.
Two stents were used in 12% versus 34%; 3 stents in 8% versus 38% of
the patients (P<0.001). After a follow up of 700 days (450-890), there
was no difference in myocardial infarction (6% vs. 6%, P=0.86), while
MACE (11% vs. 16%, P=0.06), target vessel revascularization (2% vs.
4%, P=0.15) and stent thrombosis rates (0% vs. 2.7%, P=0.26) were
numerically lower for the OCT-guided cohort but none of these endpoints
did reach statistical significance. Conclusions. An OCT-guided approach
reduced the number of stents used, number of patients treated with more
than one stent, while there was no statistically significant difference
in clinical endpoints while most of them were numerically lower,
including stent thrombosis rates. (c) 2016 Wiley Periodicals, Inc.
ER -