TY - JOUR
TI - Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave
elastography: An individual patient data-based meta-analysis
AU - Herrmann, Eva
AU - de Ledinghen, Victor
AU - Cassinotto, Christophe and
AU - Chu, Winnie C. -W.
AU - Leung, Vivian Y. -F.
AU - Ferraioli, Giovanna and
AU - Filice, Carlo
AU - Castera, Laurent
AU - Vilgrain, Valerie
AU - Ronot,
AU - Maxime
AU - Dumortier, Jerome
AU - Guibal, Aymeric
AU - Pol, Stanislas and
AU - Trebicka, Jonel
AU - Jansen, Christian
AU - Strassburg, Christian and
AU - Zheng, Rongqin
AU - Zheng, Jian
AU - Francque, Sven
AU - Vanwolleghem,
AU - Thomas
AU - Vonghia, Luisa
AU - Manesis, Emanuel K.
AU - Zoumpoulis, Pavlos
AU - and Sporea, Ioan
AU - Thiele, Maja
AU - Krag, Aleksander
AU - Cohen-Bacrie,
AU - Claude
AU - Criton, Aline
AU - Gay, Joel
AU - Deffieux, Thomas and
AU - Friedrich-Rust, Mireen
JO - Gastroenterologie a Hepatologie
PY - 2018
VL - 67
TODO - 1
SP - 260-272
PB - Wiley
SN - null
TODO - 10.1002/hep.29179
TODO - null
TODO - Two-dimensional shear wave elastography (2D-SWE) has proven to be
efficient for the evaluation of liver fibrosis in small to
moderate-sized clinical trials. We aimed at running a larger-scale
meta-analysis of individual data. Centers which have worked with
Aixplorer ultrasound equipment were contacted to share their data.
Retrospective statistical analysis used direct and paired receiver
operating characteristic and area under the receiver operating
characteristic curve (AUROC) analyses, accounting for random effects.
Data on both 2D-SWE and liver biopsy were available for 1,134 patients
from 13 sites, as well as on successful transient elastography in 665
patients. Most patients had chronic hepatitis C (n=379), hepatitis B
(n=400), or nonalcoholic fatty liver disease (n=156). AUROCs of 2D-SWE
in patients with hepatitis C, hepatitis B, and nonalcoholic fatty liver
disease were 86.3%, 90.6%, and 85.5% for diagnosing significant
fibrosis and 92.9%, 95.5%, and 91.7% for diagnosing cirrhosis,
respectively. The AUROC of 2D-SWE was 0.022-0.084 (95% confidence
interval) larger than the AUROC of transient elastography for diagnosing
significant fibrosis (P=0.001) and 0.003-0.034 for diagnosing cirrhosis
(P=0.022) in all patients. This difference was strongest in hepatitis B
patients. Conclusion: 2D-SWE has good to excellent performance for the
noninvasive staging of liver fibrosis in patients with hepatitis B;
further prospective studies are needed for head-to-head comparison
between 2D-SWE and other imaging modalities to establish
disease-specific appropriate cutoff points for assessment of fibrosis
stage. (Hepatology 2018;67:260-272).
ER -