TY - JOUR
TI - Antioxidant treatment in peripheral artery disease: the rationale is
there, but what about clinical results?
AU - Giannopoulos, Georgios
AU - Angelidis, Christos
AU - Vogiatzi, Georgia and
AU - Cleman, Michael W.
AU - Deftereos, Spyridon
JO - Current Opinion in Pharmacology
PY - 2018
VL - 39
TODO - null
SP - 53-59
PB - Elsevier Sci Ltd, Exeter, United Kingdom
SN - 1471-4892
TODO - 10.1016/j.coph.2018.01.008
TODO - null
TODO - Peripheral arterial disease is a major cause of morbidity and disability
and has been consistently associated with an adverse overall prognosis.
Oxidative stress has been linked to vascular disease, with several
suggested pathogenetic mechanisms, leading to various insults of the
arterial wall and, ultimately, to atherothrombotic disease. Considering
that the pathophysiological background is quite compelling, attenuation
of oxidative processes by means of various substances with antioxidant
properties has been conceived as a promising therapeutic target.
However, clinical results have been mostly disappointing and
`antioxidant' therapies are still far from being integrated into
treatment algorithms for vascular disease.
ER -