TY - JOUR
TI - Circulating plasma phospholipid fatty acids and risk of pancreatic
cancer in a large European cohort
AU - Matejcic, M.
AU - Lesueur, F.
AU - Biessy, C.
AU - Renault, A. L. and
AU - Mebirouk, N.
AU - Yammine, S.
AU - Keski-Rahkonen, P.
AU - Li, K. and
AU - Hemon, B.
AU - Weiderpass, E.
AU - Rebours, V.
AU - Boutron-Ruault, M. C.
AU - and Carbonnel, F.
AU - Kaaks, R.
AU - Katzke, V.
AU - Kuhn, T.
AU - Boeing,
AU - H.
AU - Trichopoulou, A.
AU - Palli, D.
AU - Agnoli, C.
AU - Panico, S. and
AU - Tumino, R.
AU - Sacerdote, C.
AU - Quiros, J. R.
AU - Duell, E. J. and
AU - Porta, M.
AU - Sanchez, M. J.
AU - Chirlaque, M. D.
AU - Barricarte, A. and
AU - Amiano, P.
AU - Ye, W.
AU - Peeters, P. H.
AU - Khaw, K. T. and
AU - Perez-Cornago, A.
AU - Key, T. J.
AU - Bueno-de-Mesquita, H. B. and
AU - Riboli, E.
AU - Vineis, P.
AU - Romieu, I.
AU - Gunter, M. J.
AU - Chajes,
AU - V.
JO - International Journal  of Cancer
PY - 2018
VL - 143
TODO - 10
SP - 2437-2448
PB - Wiley
SN - 0020-7136
TODO - 10.1002/ijc.31797
TODO - biomarkers; plasma phospholipids; fatty acids; tobacco smoking;
pancreatic cancer
TODO - There are both limited and conflicting data on the role of dietary fat
and specific fatty acids in the development of pancreatic cancer. In
this study, we investigated the association between plasma phospholipid
fatty acids and pancreatic cancer risk in the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid
composition was measured by gas chromatography in plasma samples
collected at recruitment from375 incident pancreatic cancer cases and375
matched controls. Associations of specific fatty acids with pancreatic
cancer risk were evaluated using multivariable conditional logistic
regression models with adjustment for established pancreatic cancer risk
factors. Statistically significant inverse associations were found
between pancreatic cancer incidence and levels of heptadecanoic acid
(ORT3-T1[odds ratio for highest versus lowest tertile] =0.63;
95%CI[confidence interval] = 0.41-0.98; p(trend) = 0.036), n-3
polyunsaturated -linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39-0.92;
p(trend) = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI =
0.32-0.85; p(trend) = 0.008). Industrial trans-fatty acids were
positively associated with pancreatic cancer risk among men (ORT3-T1 =
3.00; 95%CI = 1.13-7.99; p(trend) = 0.029), while conjugated linoleic
acids were inversely related to pancreatic cancer among women only
(ORT3-T1 = 0.37; 95%CI = 0.17-0.81; p(trend) = 0.008). Among current
smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was
positively associated with pancreatic cancer risk (ORT3-T1 = 3.40;
95%CI = 1.39-8.34; p(trend) = 0.007). Results were robust to a range of
sensitivity analyses. Our findings suggest that higher circulating
levels of saturated fatty acids with an odd number of carbon atoms and
n-3 polyunsaturated fatty acids may be related to lower risk of
pancreatic cancer. The influence of some fatty acids on the development
of pancreatic cancer may be sex-specific and modulated by smoking.
ER -