TY - JOUR
TI - Luteal phase progesterone and estradiol concentrations and their
relation to the outcome of IVF/ICSI cycles with controlled ovarian
stimulation
AU - Bakas, P.
AU - Simopoulou, M.
AU - Panagopoulos, P.
AU - Salakos, N. and
AU - Siristatidis, Ch
JO - Clinical and Experimental Obstetrics & Gynecology
PY - 2019
VL - 46
TODO - 5
SP - 727-730
PB - 7847050 Canada Inc.
SN - 0390-6663
TODO - 10.12891/ceog4741.2019
TODO - Estradiol; Progesterone; Ganirelix; Controlled ovarian stimulation; COS;
IVF; ICSI
TODO - Purpose of Investigation: To examine if the potential changes in
progesterone (P) and estradiol (E2) levels during the luteal phase can
predict the outcome in IVF/ICSI cycles. Material and Methods: A
prospective study of 282 patients with infertility undergoing IVF/ICSI
have been included. Serum E2 and P measurements at day of hCG triggering
and days 6 and 10 after embryo transfer in conception and non-conception
cycles. Results: The ROC curve in predicting clinical pregnancy was
calculated at 0.864 (95% CI: 0.841-0.92). A maximum reduction of <= 32
% demonstrated sensitivity of 84.3% and specificity of 80.4%. The
corresponding ROC curve for percentage change in P levels was 0.733 with
95% CI: 0.334-0.96. Conclusion: A maximum reduction of 32 % in E2
levels between days 6 and 10 after embryo transfer demonstrated a
predictive ability for clinical pregnancy after IVF/ICSI of 86.4% with
sensitivity 84.3% and specificity 80.4%.
ER -