TY - JOUR
TI - Unmet Needs in Appendiceal Neuroendocrine Neoplasms
AU - Toumpanakis, Christos
AU - Fazio, Nicola
AU - Janson, Eva Tiensuu and
AU - Horsch, Dieter
AU - Pascher, Andreas
AU - Reed, Nicholas
AU - O'Toole,
AU - Dermot
AU - van Dijkum, Els Nieveen
AU - Partelli, Stefano
AU - Rinke, Anja
AU - and Kos-Kudla, Beata
AU - Costa, Frederico
AU - Pape, Ulrich-Frank and
AU - Grozinsky-Glasberg, Simona
AU - Scoazec, Jean-Yves
AU - Detlef, Bartsch
AU - and Rudolf, Arnold
AU - Eric, Baudin
AU - Lisa, Bodei
AU - Ivan, Borbath
AU - and Jaume, Capdevila
AU - Martyn, Caplin
AU - Jie, Chen
AU - Frederico,
AU - Costa
AU - Anne, Couvelard
AU - Jaroslaw, Cwikla B.
AU - de Herder, Wouter
AU - W.
AU - Massimo, Falconi
AU - Jenny, Falkerby
AU - Nicola, Fazio
AU - Diego,
AU - Ferone
AU - Andrea, Frilling
AU - Rocio, Garcia-Carbonero
AU - Simona,
AU - Glasberg
AU - Vera, Gorbunova
AU - Ashley, Grossman
AU - Dieter, Hoersch
AU - and Robert, Jensen
AU - Gregory, Kaltsas
AU - Guenter, Kloeppel
AU - Peter,
AU - Knigge Ulrich
AU - Beata, Kos-Kudla
AU - Guenter, Krejs J.
AU - Eric,
AU - Krenning
AU - Matthew, Kulke
AU - Steven, Lamberts W. J.
AU - Elisabeth,
AU - Nieveen van Dijkum
AU - Juan Manuel, O'Connor
AU - Dermot, O'Toole and
AU - Ulrich-Frank, Pape
AU - Stefano, Partelli
AU - Ellen, Pavel Marianne and
AU - Marc, Peeters
AU - John, Ramage
AU - Nicholas, Reed
AU - Guido, Rindi and
AU - Anja, Rinke
AU - Philippe, Ruszniewski
AU - Halfdan, Sorbye
AU - Anders,
AU - Sundin
AU - Jean-Yves, Scoazec
AU - Babs, Taal G.
AU - Eva, Tiensuu Janson
AU - and Christos, Toumpanakis
AU - Juan, Valle
AU - Marie-Pierre, Vullierme
AU - and Staffan, Welin
AU - Bertram, Wiedenmann
AU - ENETS 2016 Munich
AU - Advisory Board
JO - ISRN Neuroendocrinology
PY - 2019
VL - 108
TODO - 1
SP - 37-44
PB - Karger
SN - 2090-7982
TODO - 10.1159/000493894
TODO - Appendix; Carcinoids; Appendiceal neuroendocrine neoplasms;
Appendicectomy; Right hemicolectomy
TODO - Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered
coincidentally during appendicectomy and usually have a benign clinical
course; thus, appendicectomy alone is considered curative. However, in
some cases, a malignant potential is suspected, and therefore additional
operations such as completion right hemicolectomy are considered. The
existing European Neuroendocrine Tumour Society (ENETS) guidelines
provide useful data about epidemiology and prognosis, as well as
practical recommendations with regards to the risk factors for a more
aggressive disease course and the indications for a secondary operation.
However, these guidelines are based on heterogeneous and retrospective
studies. Therefore, the evidence does not seem to be robust, and there
are still unmet needs in terms of accurate epidemiology and overall
prognosis, optimal diagnostic and follow-up strategy, as well as
identified risk factors that would indicate a more aggressive surgical
approach at the beginning and a more intense follow-up. In this review,
we are adopting a critical approach of the ENETS guidelines and
published series for ANEN, focusing on the above-noted grey areas.
ER -