TY - JOUR
TI - Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need
AU - Ramage, John K.
AU - Valle, Juan W.
AU - van Dijkum, Els J. M. Nieveen and
AU - Sundin, Anders
AU - Pascher, Andreas
AU - Couvelard, Anne
AU - Kloeppel,
AU - Guenter
AU - Bartsch, Detlef
AU - Arnold, Rudolf
AU - Baudin, Eric and
AU - Bodei, Lisa
AU - Borbath, Iva
AU - Capdevila, Jaume
AU - Caplin, Matyn and
AU - Chen, Jie
AU - Costa, Frederico
AU - Couvelard, Anne
AU - Cwikla, Jaroslaw
AU - B.
AU - Davies, Philippa
AU - de Herder, Wouter W.
AU - Falconi, Massimo
AU - and Falkerby, Jenny
AU - Fazio, Nicola
AU - Ferone, Diego
AU - Frilling,
AU - Andrea
AU - Garcia-Carbonero, Rocio
AU - Glasberg, Simona
AU - Gorbunova,
AU - Vera
AU - Grossman, Ashley
AU - Hoersch, Dieter
AU - Jensen, Robert and
AU - Kaltsas, Gregory
AU - Kloeppel, Guenter
AU - Kingge, Ulrich Peter and
AU - Kos-Kudla, Beata
AU - Krejs, Guenter J.
AU - Krenning, Eric
AU - Kulke,
AU - Matthew
AU - Lamberts, Steven W. J.
AU - Van Dijkum, Nieveen Els J. M. and
AU - O'Connor, Juan Manuel
AU - O'Toole, Dermot
AU - Pape, Ulrich-Frank and
AU - Partelli, Stefano
AU - Pavel, Marianne Ellen
AU - Peeters, Marc and
AU - Ramage, John K.
AU - Reed, Nicholas Simon
AU - Rindi, Guido
AU - Rinke,
AU - Anja
AU - Ruszniewski, Philippe
AU - Sorbye, Halfdan
AU - Sundin, Anders
AU - and Scoazec, Jean-Yves
AU - Taal, Babs G.
AU - Janson, Tiensuu Eva and
AU - Toumpanakis, Christos
AU - Valle, Juan W.
AU - Vullierme, Marie-Pierre and
AU - Staffan, Welin
AU - Wiedenmann, Bertman
AU - ENETS 2016 Munich Advisory
AU - Board
JO - ISRN Neuroendocrinology
PY - 2019
VL - 108
TODO - 1
SP - 45-53
PB - Karger
SN - 2090-7982
TODO - 10.1159/000493767
TODO - Carcinoid tumours; Gastroenteropancreatic neuroendocrine tumours;
Neuroendocrine tumour; Somatostatin receptor
TODO - The subject of colorectal neuroendocrine neoplasms (NENs), subdivided
into well-differentiated NENs, termed neuroendocrine tumours (NETs;
grade (G) 1 and 2), and poorly differentiated NENs, termed
neuroendocrine carcinomas (NECs; G3) according to the 2010 World Health
Organisation (WHO) classification, has arguably not had as much
attention or study as NENs occurring in other sites. Colorectal NETs and
NECs are however easier to study than many others since they are usually
not difficult to remove and are increasingly detected because of
intensified colorectal cancer screening and surveillance programmes.
Colorectal NETs and NECs show site-specific heterogeneity with variable
behaviour and different therapeutic options; these various aspects
provide unique challenges. Because of bowel cancer screening programmes,
colorectal NENs, like conventional adenocarcinomas, may be diagnosed at
a stage that is associated with improved survival. In this article we
intend to describe and define areas of unmet needs relating to the
epidemiology, classification, pathology, diagnosis and therapy of
colorectal NETs (including NETs G3), colorectal NECs, and finally, mixed
adeno-neuroendocrine carcinomas (MANECs) by reviewing and discussing the
relevant literature.
ER -