TY - JOUR
TI - Using research to prepare for outbreaks of severe acute respiratory
infection
AU - Mich, Vann
AU - Pho, Yaty
AU - Bory, Sotharith
AU - Vann, Mich
AU - Teav,
AU - Bunlor
AU - Som, Leakhann
AU - Jarrvisalo, Mikko J.
AU - Pulkkinen, Anni
AU - and Kuitunen, Anne
AU - Ala-kokko, Tero
AU - Melto, Sari
AU - Daix, Thomas
AU - and Philippart, Francois
AU - Antoine, Marchalot
AU - Tiercelet, Kelly and
AU - Bruel, Cedric
AU - Nicholas, Sedillot
AU - Siami, Shidasp
AU - Fabienne,
AU - Taimon
AU - Bruyere, Raomi
AU - Forceville, Xavier
AU - Erickson, Simon and
AU - Campbell, Lewis
AU - Sonawane, Ravikiran
AU - Santamaria, John
AU - Kol,
AU - Mark
AU - Awasthi, Shally
AU - Powis, Jeff
AU - Hall, Richard
AU - McCarthy,
AU - Anne E.
AU - Jouvet, Philippe
AU - Opaysky, Mary Anne
AU - Gilfoyle, Elaine
AU - and Farshait, Nataly
AU - Martin, Dori-Ann
AU - Griesdale, Donald and
AU - Katz, Kevin
AU - Ruberto, Aaron J.
AU - Carrier, Francois Martin and
AU - Lamontagne, Francois
AU - Muscedere, John
AU - Rishu, Asgar
AU - Sin, Wai
AU - Ching
AU - Ngai, Wallace Chun Wai
AU - Young, Paul
AU - Forrest, Annette
AU - and Kazemi, Alex
AU - Henderson, Seton
AU - Browne, Troy and
AU - Ganeshalingham, Anusha
AU - McConnochie, Rachael
AU - Cho, Jae Hwa and
AU - Park, Tai Sun
AU - Sim, Yun Su
AU - Chang, Youjin
AU - Lee, Heung Bum and
AU - Park, Seung Yong
AU - Chan, Wai Ming
AU - Lee, Won-Yeon
AU - Wallace, David
AU - J.
AU - Angus, Derek C.
AU - Charles, Anthony G.
AU - van Doom, H. Rogier
AU - and Nguyen Van Kinh
AU - Nguyen Vu Trung
AU - Prin, Meghan and
AU - Twagirumugabe, Theogene
AU - Umuhire, Olivier Felix
AU - Sylvain,
AU - Habarurema
AU - Al Qasim, Eman
AU - Heraud, Jean-Michel
AU - Raberahona,
AU - Mihaja
AU - Rabarison, Joelinotahiana Hasina
AU - Patrigeon, Santiago
AU - Perez
AU - Ramirez-Venegas, Alejandra
AU - Melendez, Javier Araujo and
AU - Guerrero, M. Lourdes
AU - Mambule, Ivan
AU - Ochieng, Otieno George and
AU - Nadjm, Behzad
AU - Li, Iris Wai Sum
AU - Choi, Won-Il
AU - Florence,
AU - Komurian-Pradel
AU - Arabi, Yaseen M.
AU - West, T. Eoin
AU - Riviello,
AU - Elisabeth D.
AU - Parke, Rachael
AU - Djillali, Annane E.
AU - Fowler,
AU - Robert
AU - Murthy, Srinivas
AU - Nichol, Alistair
AU - Cheng, Allen C. and
AU - Semple, Calum
AU - George, Maya
AU - Valkonen, Miia
AU - McArthur, Colin
AU - and Carson, Gail
AU - O'Neill, Genevieve
AU - Cobb, J. Perren
AU - Dunning,
AU - Jake
AU - Chiche, Jean-Daniel
AU - Huh, Jin-Won
AU - Marshall, John and
AU - Rello, Jordi
AU - Guillebaud, Julia
AU - Razanazatovo, Norosoa
AU - Otieno,
AU - Juilett Wambura
AU - Green, Karen
AU - Rowan, Kathy
AU - Baillie, John
AU - Kenneth
AU - Merson, Laura
AU - Hsu, Li Yang
AU - Christian, Michael D. and
AU - Egi, Moritoki
AU - Shindo, Nahoko
AU - Horby, Peter
AU - Pardinaz-Solis,
AU - Raul
AU - Ubiergo, Sebastian Ugarte
AU - Webb, Steve A. R.
AU - Uyeki,
AU - Timothy M.
AU - Gordon, Anthony C.
AU - Paterson, David L.
AU - Everett,
AU - Dean
AU - Giamarellos-Bourboulis, Evangelos J.
AU - Longuere, Kajsa-Stina
AU - and Maslove, David
AU - Ohuma, Eric
AU - Growl, Gloria
AU - PedutemHumber,
AU - Theresa
AU - EllazarHumber, Edward
AU - Bahinskaya, Ilona and
AU - Osbourne-Townsend, Joan
AU - Bentley, Andrew
AU - Goodson, Jennifer and
AU - Welters, Ingeborg
AU - Malik, Nadia
AU - Browne, T. S.
AU - Mahesh, Vinaya
AU - and SPRINT-SARI Investigators
JO - BMJ Global Health
PY - 2019
VL - 4
TODO - 1
SP - null
PB - BMJ Publishing Group
SN - 2059-7908
TODO - 10.1136/bmjgh-2018-001061
TODO - null
TODO - Severe acute respiratory infections (SARI) remain one of the leading
causes of mortality around the world in all age groups. There is large
global variation in epidemiology, clinical management and outcomes,
including mortality. We performed a short period observational data
collection in critical care units distributed globally during regional
peak SARI seasons from 1 January 2016 until 31 August 2017, using
standardised data collection tools. Data were collected for 1 week on
all admitted patients who met the inclusion criteria for SARI, with
follow-up to hospital discharge. Proportions of patients across regions
were compared for microbiology, management strategies and outcomes.
Regions were divided geographically and economically according to World
Bank definitions. Data were collected for 682 patients from 95 hospitals
and 23 countries. The overall mortality was 9.5%. Of the patients,
21.7% were children, with case fatality proportions of 1% for those
less than 5 years. The highest mortality was in those above 60 years, at
18.6%. Case fatality varied by region: East Asia and Pacific 10.2% (21
of 206), Sub-Saharan Africa 4.3% (8 of 188), South Asia 0% (0 of 35),
North America 13.6% (25 of 184), and Europe and Central Asia 14.3% (9
of 63). Mortality in low-income and low-middle-income countries combined
was 4% as compared with 14% in high-income countries. Organ
dysfunction scores calculated on presentation in 560 patients where full
data were available revealed Sequential Organ Failure Assessment (SOFA)
scores on presentation were significantly associated with mortality and
hospital length of stay. Patients in East Asia and Pacific (48%) and
North America (24%) had the highest SOFA scores of >12. Multivariable
analysis demonstrated that initial SOFA score and age were independent
predictors of hospital survival. There was variability across regions
and income groupings for the critical care management and outcomes of
SARI. Intensive care unit-specific factors, geography and management
features were less reliable than baseline severity for predicting
ultimate outcome. These findings may help in planning future outbreak
severity assessments, but more globally representative data are
required.
ER -