TY - JOUR
TI - High Rates of Prescribing Antimicrobials for Prophylaxis in Children and
Neonates: Results From the Antibiotic Resistance and Prescribing in
European Children Point Prevalence Survey
AU - Hufnagel, Markus
AU - Versporten, Ann
AU - Bielicki, Julia
AU - Drapier,
AU - Nico
AU - Sherland, Mike
AU - Goossens, Herman
AU - Maria Calle, Graciela
AU - and Clark, Julia
AU - Cooper, Celia
AU - Blyth, Christopher C. and
AU - Francis, Joshua Reginald
AU - Alsalman, Jameela
AU - Jansen, Hilde and
AU - Mahieu, Ludo
AU - Van Rossom, Paul
AU - Vandewal, Wouter
AU - Lepage,
AU - Philippe
AU - Blumental, Sophie
AU - Briquet, Caroline
AU - Robbrecht, Dirk
AU - and Maton, Pierre
AU - Gabriels, Patrick
AU - Rubic, Zana
AU - Kovacevic,
AU - Tanja
AU - Nielsen, Jens Peter
AU - Petersen, Jes Reinholdt and
AU - Poorisrisak, Porntiva
AU - Jensen, Lise Heilmann
AU - Laan, Mari
AU - Tamm,
AU - Eda
AU - Matsinen, Maire
AU - Rummukainen, Maija-Liisa
AU - Gajdos, Vincent
AU - and Olivier, Romain
AU - Le Marechal, Flore
AU - Martinot, Alain and
AU - Dubos, Francois
AU - Lagree, Marion
AU - Prot-Labarthe, Sonia
AU - Lorrot,
AU - Mathie
AU - Orbach, Daniel
AU - Pagava, Karaman
AU - Knuf, Markus and
AU - Schlag, Stephanie A. A.
AU - Liese, Johannes
AU - Renner, Lorna and
AU - Enimil, Anthony
AU - Awunyo, Marah
AU - Syridou, Garyfallia
AU - Spyridis,
AU - Nikos
AU - Critselis, Elena
AU - Kouni, Sofia
AU - Mougkou, Katerina and
AU - Ladomenou, Fani
AU - Gkentzi, Despoina
AU - Iosifidis, Elias
AU - Roilides,
AU - Emmanuel
AU - Sahu, Suneeta
AU - Murki, Srinivas
AU - Malviya, Manoj and
AU - Kalavalapalli, Durga Bhavani
AU - Singh, Sanjeev
AU - Singhal, Tanu and
AU - Garg, Garima
AU - Garg, Pankaj
AU - Kler, Neelam
AU - Soltani, Jafar and
AU - Jafarpour, Zahra
AU - Pouladfar, Gholamreza
AU - Nicolini, Giangiacomo and
AU - Montagnani, Carlotta
AU - Galli, Luisa
AU - Esposito, Susanna
AU - Tenconi,
AU - Rossana
AU - Lo Vecchio, Andrea
AU - Dona, Daniele
AU - Giaquinto, Carlo
AU - and Borgia, Eleonora
AU - D'Argenio, Patrizia
AU - De Luca, Maia and
AU - Centenari, Chiara
AU - Raka, Lul
AU - Raka, Denis
AU - Omar, Abeer and
AU - Al-Mousa, Haifaa
AU - Mozgis, Dzintars
AU - Sviestina, Inese and
AU - Burokiene, Sigita
AU - Usonis, Vytautas
AU - Tavchioska, Gabriela and
AU - Hargadon-Lowe, Antonia
AU - Zarb, Peter
AU - Borg, Michael A.
AU - Gonzalez
AU - Lozano, Carlos Agustin
AU - Zarate Castanon, Patricia
AU - Cancino, Martha
AU - E.
AU - McCullagh, Bernadette
AU - McCorry, Ann
AU - Gormley, Cairine and
AU - Al Maskari, Zaina
AU - Al-Jardani, Amina
AU - Pluta, Magdalena and
AU - Rodrigues, Fernanda
AU - Brett, Ana
AU - Esteves, Isabel
AU - Marques,
AU - Laura
AU - AlAjmi, Jameela Ali
AU - Cambrea, Simona Claudia
AU - Rashed,
AU - Asia N.
AU - Al Azmi, Aeshah Abdu Mubarak
AU - Chan, Si Min
AU - Isa, Mas
AU - Suhaila
AU - Najdenov, Peter
AU - Cizman, Milan
AU - Unuk, Sibila and
AU - Finlayson, Heather
AU - Dramowski, Angela
AU - Mate-Cano, Irene
AU - Soto,
AU - Beatriz
AU - Calvo, Cristina
AU - Santiago, Begona
AU - Saavedra-Lozano,
AU - Jesus
AU - Bustinza, Amaya
AU - Escosa-Garcia, Luis
AU - Ureta, Noelia and
AU - Lopez-Varela, Elisa
AU - Rojo, Pablo
AU - Tagarro, Alfredo
AU - Terol
AU - Barrero, Pedro
AU - Maria Rincon-Lopez, Elena
AU - Abubakar, Ismaela and
AU - Aston, Jeff
AU - Patel, Mitul
AU - Russell, Alison Bedford and
AU - Heginbothom, Maggie
AU - Satodia, Prakash
AU - Garbash, Mehdi
AU - Johnson,
AU - Alison
AU - Sharpe, David
AU - Barton, Christopher
AU - Menson, Esse and
AU - Arenas-Lopez, Sara
AU - Luck, Suzanne
AU - Doerholt, Katja
AU - McMaster,
AU - Paddy
AU - Caldwell, Neil A.
AU - Lunn, Andrew
AU - Drysdale, Simon B. and
AU - Howe, Rachel
AU - Scorrer, Tim
AU - Gahleitner, Florian
AU - Gupta, Richa
AU - and Nash, Clare
AU - Alexander, John
AU - Raman, Mala
AU - Bell, Emily and
AU - Rajagopal, Veena
AU - Kohlhoff, Stephan
AU - Cox, Elaine
AU - Nichols,
AU - Kristen
AU - Zaoutis, Theoklis
AU - ARPEC Project Grp
JO - Journal of the Pediatric Infectious Diseases Society
PY - 2019
VL - 8
TODO - 2
SP - 143-151
PB - Oxford University Press
SN - 2048-7193, 2048-7207
TODO - 10.1093/jpids/piy019
TODO - antimicrobials; inpatients; pediatrics; point-prevalence survey;
prophylactic prescribing
TODO - Background. This study was conducted to assess the variation in
prescription practices for systemic antimicrobial agents used for
prophylaxis among pediatric patients hospitalized in 41 countries
worldwide.
Methods. Using the standardized Antibiotic Resistance and Prescribing in
European Children Point Prevalence Survey protocol, a cross-sectional
point-prevalence survey was conducted at 226 pediatric hospitals in 41
countries from October 1 to November 30, 2012.
Results. Overall, 17 693 pediatric patients were surveyed and 36.7% of
them received antibiotics (n = 6499). Of 6818 inpatient children, 2242
(32.9%) received at least 1 antimicrobial for prophylactic use. Of 11
899 prescriptions for antimicrobials, 3400 (28.6%) were provided for
prophylactic use. Prophylaxis for medical diseases was the indication in
73.4% of cases (2495 of 3400), whereas 26.6% of prescriptions were for
surgical diseases (905 of 3400). In approximately half the cases (48.7%
[1656 of 3400]), a combination of 2 or more antimicrobials was
prescribed. The use of broad-spectrum antibiotics (BSAs), which included
tetracyclines, macrolides, lincosamides, and sulfonamides/trimethoprim,
was high (51.8% [1761 of 3400]). Broad-spectrum antibiotic use for
medical prophylaxis was more common in Asia (risk ratio [RR], 1.322;
95% confidence interval [CI], 1.202-1.653) and more restricted in
Australia (RR, 0.619; 95% CI, 0.521-0.736). Prescription of BSA for
surgical prophylaxis also varied according to United Nations region.
Finally, a high percentage of surgical patients (79.7% [721 of 905])
received their prophylaxis for longer than 1 day.
Conclusions. A high proportion of hospitalized children received
prophylactic BSAs. This represents a clear target for quality
improvement. Collectively speaking, it is critical to reduce total
prophylactic prescribing, BSA use, and prolonged prescription.
ER -