TY - JOUR
TI - Extensive validation study of the Parkinson's Disease Composite Scale
AU - Martinez-Martin, P.
AU - Radicati, F. G.
AU - Rodriguez Blazquez, C. and
AU - Wetmore, J.
AU - Kovacs, N.
AU - Chaudhuri, K. Ray
AU - Stocchi, F. and
AU - Vuletic, Vladimira
AU - Falup-Pecurariu, Cristian
AU - Diaconu, Stefania
AU - and Johansson, Anders
AU - Sundgren, Mathias
AU - Simitsi, Athima and
AU - Stefanis, Leonidas
AU - Gurevich, Tanya
AU - Migirov-Sanderovich, Angel
AU - and Ezra, Adi
AU - Guekht, Alla
AU - Popov, Georgy
AU - Stamelou, Maria and
AU - Giagkou, Nikolaos
AU - Stefani, Alessandro
AU - Cerroni, Rocco
AU - Corbo,
AU - Massimo
AU - Grassi, Andrea
AU - Dellaporta, Dionysia
AU - Tsolaki, Magda
AU - and Ariadne, Vakirli
AU - Kefalopoulou, Zinovia
AU - Ellul, John
AU - Mir,
AU - Pablo
AU - Adarmes, Astrid D.
AU - Mendez-del-Barrio, Carlota and
AU - Skorvanek, Matej
AU - Necpal, Jan
AU - Bostantjopoulou, Sevasti
AU - Zoe,
AU - Katsarou
AU - Minar, Michal
AU - Simu, Mihaela
AU - Rosca, Cecilia and
AU - Popovici, Maria
AU - Kostic, Vladimir S.
AU - Marti, Maria J. and
AU - Planelles, Lluis
AU - Kovacs, Norbert
AU - Aschermann, Zsuzsanna and
AU - Juhasz, Annamaria
AU - Harmat, Mark
AU - PDCS European Study Grp
JO - European Journal of Paediatric Neurology
PY - 2019
VL - 26
TODO - 10
SP - 1281-1288
PB - Wiley
SN - 1090-3798
TODO - 10.1111/ene.13976
TODO - dimensionality; inter-rater reliability; Parkinson's disease;
Parkinson's Disease Composite Scale; validation
TODO - Background and purpose A composite instrument able to rapidly and
reliably assess the most relevant motor and non-motor afflictions
suffered by Parkinson’s disease (PD) patients in a real world clinic
setting is an unmet need. The recently validated PD Composite Scale
(PDCS) was designed to fulfil this gap as a quick, comprehensive PD
assessment. The objective of this study was extensive evaluation of the
PDCS’s clinimetric properties using a large international sample.
Methods This was a cross-sectional study in which the PDCS, the Movement
Disorder Society Unified Parkinson’s Disease Rating Scale and the
Clinical Impression of Severity Index for PD were applied. Basic
clinimetric attributes of the PDCS were analysed. Results In total, 776
PD patients were included. The PDCS total score showed negligible floor
and ceiling effects. Three factors (54.5% of the variance) were
identified: factor 1 included motor impairment, fluctuations and
disability; factor 2, non-motor symptoms; and factor 3, tremor and
complications of therapy. Cronbach’s alpha was from 0.66 to 0.79.
Inter-rater reliability showed weighted kappa values from 0.79 to 0.98
for items and intraclass correlation coefficient values from 0.95
(Disability) to 0.99 (Motor and total score). The Bland-Altmann method,
however, showed irregular concordance. PDCS standard error of
measurement and convergent validity with equivalent constructs of other
measures were satisfactory (>= 0.70). PDCS scores significantly differed
by Hoehn and Yahr stage. Conclusion Overall, in line with previous
findings, the PDCS is a feasible, acceptable, valid, reliable and
precise instrument for quickly and comprehensively assessing PD
patients.
ER -