TY - JOUR
TI - Growth and Puberty in Juvenile Dermatomyositis: A Longitudinal Cohort
Study
AU - Nordal, Ellen
AU - Pistorio, Angela
AU - Rygg, Marite
AU - Giancane,
AU - Gabriella
AU - Maghnie, Mohamad
AU - Di Iorgi, Natascia
AU - Flemming,
AU - Kristina
AU - Hofer, Michael
AU - Melo-Gomes, Jose A.
AU - Bica, Blanca E.
AU - R. G.
AU - Brunner, Jurgen
AU - Dannecker, Guenther
AU - Gerloni, Valeria
AU - and Harjacek, Miroslav
AU - Huppertz, Hans-Iko
AU - Pratsidou-Gertsi,
AU - Polyxeni
AU - Nielsen, Susan
AU - Stanevicha, Valda
AU - Ten Cate, Rebecca
AU - and Vougiouka, Olga
AU - Pastore, Serena
AU - Simonini, Gabriele and
AU - Ravelli, Angelo
AU - Martini, Alberto
AU - Ruperto, Nicolino
AU - Paediat
AU - Rheumatology Int Trials
JO - ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
PY - 2020
VL - 72
TODO - 2
SP - 265-273
PB - Wiley
SN - null
TODO - 10.1002/acr.24065
TODO - null
TODO - Objective To study growth and puberty in a multinational longitudinal
prospective cohort of children with juvenile dermatomyositis (DM).
Methods Children from 31 countries who were ages DM in active phase were
studied, and analyses of height, weight, and pubertal development were
conducted in those who had follow-up visits during a 2-year period and
for whom anthropometric data was available. Results A total of 196 of
275 children (71%) were included. We found a significant reduction in
parent-adjusted height Z score over time in female patients (P < 0.0001)
and male patients (P = 0.001), but with catch-up growth at the final
study visit. Median body mass index Z score peaked at 6 months (P <
0.0001) and was still significantly above baseline at the final study
visit, which was at a median of 26 months after baseline (P = 0.007),
with no difference between sexes. Female patients with a disease
duration >= 12 months after onset had significantly lower
parent-adjusted height Z score (P = 0.002) and no 2-year catch-up
growth. At the final study visit, growth failure was seen in 20 of 97
female patients (21%) and in 11 of 73 male patients (15%). Height
deflection ( increment height Z score less than -0.25/year) was observed
in 29 of 116 female patients (25%) and 25 of 80 male patients (31.3%).
Delayed puberty was seen in 20 of 55 female patients (36.4%) and in 11
of 31 male patients (35.5%). Children in early pubertal stage at
baseline had the highest risk of growth failure. Conclusion Juvenile DM
in the active phase and/or its treatment has a significant impact on
growth and puberty in affected children. Children with recent onset of
puberty or previous growth failure have the highest risk of delayed
pubertal development and further growth retardation.
ER -