TY - JOUR
TI - Profiles of criteria and non-criteria anti-phospholipid autoantibodies
are associated with clinical phenotypes of the antiphospholipid syndrome
AU - Volkov, Ilan
AU - Seguro, Luciana
AU - Leon, Elaine P.
AU - Kovacs, Laszlo
AU - and Roggenbuck, Dirk
AU - Schierack, Peter
AU - Gilburd, Boris
AU - Doria,
AU - Andrea
AU - Tektonidou, Maria G.
AU - Agmon-Levin, Nancy
JO - Autoimmunity Highlights
PY - 2020
VL - 11
TODO - 1
SP - null
PB - Springer-Verlag
SN - 2038-0305, 2038-3274
TODO - 10.1186/s13317-020-00131-3
TODO - Anti-phospholipid syndrome; Antiphospholipid antibody; Anti-cardiolipin;
Anti-beta 2GP1; Anti-prothrombin; Phosphatidic acid;
Anti-phosphatidylcholine; Anti-phosphatidylethanolamine;
Anti-phosphatidylglycerol; Anti-phosphatidylinositol;
Anti-phosphatidylserine; Anti-annexin 5; Phenotypes
TODO - Background Specific anti-phospholipids antibodies (aPLs) are used as
classification criteria of the antiphospholipid syndrome (APS). These
aPLs, although essential for diagnosis, do not predict disease
phenotypes, which may require specific therapies. Non-criteria aPLs are
rarely evaluated and their role is yet to be defined. In the current
study, we aimed to examine the association between criteria and
non-criteria aPLs and APS phenotypes. Methods Serum samples from 188
subjects, 130 APS patients and 58 controls were analyzed for the
presence of 20 aPLs (IgG and IgM isotypes to cardiolipin (CL),
beta2-glycoprotein1 (beta 2GP1), phosphatidic acid (P-acid),
phosphatidylcholine (PC), phosphatidylethanolamine (PE),
phosphatidylglycerol (PG), phosphatidylinositol (PI), phosphatidylserine
(PS), annexin-5 (AN) and prothrombin (PT) using a line immunoassay (GA
Generic Assays, Germany). Sero-positivity to the different aPLs/aPLs
profiles was correlated to APS phenotypes (i.e. arterial thrombosis, CNS
manifestations, venous thrombosis, relapsing disease, obstetric
morbidity). Results In this cohort, arterial thrombosis was associated
with accumulative number of >= 7/20 aPLs evaluated (OR 4.1; CI 95%
1.9-96, p = 0.001) as well as the sole presence of aPT (IgG) (OR 2.3;CI
95% 1.1-5.1, p = 0.03). CNS manifestations were linked with a profile
of 4 aPLs (IgG): aPT, aPG, aPI and aAN (OR 2.6;CI 95% 1.1-6.3, p =
0.03). Symptom-free period of >= 3 years was linked with lower number of
aPLs and the presence of aPI (IgG) (OR 3.0;CI 95% 1.08-8.1, p < 0.05)
or aAN (IgG) (OR 3.4;CI 95% 1.08-10.9, p < 0.05). APS related pregnancy
morbidity correlated with a profile of 2 aPLs (IgG): aCL and aPS (OR
2.9; CI 95% 1.3-6.5, p < 0.05) or the sole presence of aAN (IgG) (OR
2.8; CI 95% 1.02-8, p = 0.05). Conclusion In this study, we observed an
association between specific criteria/non-criteria aPLs or aPLs profiles
and clinical phenotypes of APS. Our data suggest that examination of a
wider variety of aPLs may allow better characterization of APS.
ER -