TY - JOUR
TI - Cranial and ventricular size following shunting or endoscopic third
ventriculostomy (ETV) in infants with aqueductal stenosis: further
insights from the International Infant Hydrocephalus Study (IIHS)
AU - Coulter, Ian C.
AU - Kulkarni, Abhaya V.
AU - Sgouros, Spyros and
AU - Constantini, Shlomi
AU - Constantini, Shlomi
AU - Sgouros, Spyros and
AU - Kulkarni, Abhaya V.
AU - Leitner, Yael
AU - Kestle, John R. W. and
AU - Cochrane, Douglas D.
AU - Choux, Maurice
AU - Gjerris, Fleming
AU - Sherer,
AU - Adina
AU - Akalan, Nejat
AU - Bilginer, Burcak
AU - Navarro, Ramon and
AU - Vujotic, Ljiljana
AU - Haberl, Hannes
AU - Thomale, Ulrich-Wilhelm and
AU - Zuccaro, Graciela
AU - Jaimovitch, Roberto
AU - Frim, David
AU - Loftis,
AU - Lori
AU - Swift, Dale M.
AU - Robertson, Brian
AU - Gargan, Lynn and
AU - Bognar, Laszlo
AU - Novak, Laszlo
AU - Cseke, Georgina
AU - Cama, Armando
AU - and Ravegnani, Giuseppe Marcello
AU - Preuss, Matthias
AU - Schroeder,
AU - Henry W.
AU - Fritsch, Michael
AU - Baldauf, Joerg
AU - Mandera, Marek and
AU - Luszawski, Jerzy
AU - Skorupka, Patrycja
AU - Mallucci, Conor and
AU - Williams, Dawn
AU - Zakrzewski, Krzysztof
AU - Nowoslawska, Emilia and
AU - Srivastava, Chhitij
AU - Mahapatra, Ashok K.
AU - Kumar, Raj
AU - Sahu,
AU - Rabi Narayan
AU - Melikian, Armen G.
AU - Korshunov, Anton
AU - Galstyan,
AU - Anna
AU - Suri, Ashish
AU - Gupta, Deepak
AU - Grotenhuis, J. Andre
AU - van
AU - Lindert, Erik J.
AU - da Costa Val, Jose Aloysio
AU - Di Rocco, Concezio
AU - and Tamburrini, Gianpiero
AU - Zymberg, Samuel Tau
AU - Cavalheiro, Sergio
AU - and Jie, Ma
AU - Feng, Jiang
AU - Friedman, Orna
AU - Rajmohamed, Naheeda
AU - and Roszkowski, Marcin
AU - Barszcz, Slawomir
AU - Jallo, George and
AU - Pincus, David W.
AU - Richter, Bridget
AU - Mehdorn, H. M.
AU - Schultka,
AU - Susan
AU - de Ribaupierre, Sandrine
AU - Thompson, Dominic
AU - Gatscher,
AU - Silvia
AU - Wagner, Wolfgang
AU - Koch, Dorothee
AU - Cipri, Saverio and
AU - Zaccone, Claudio
AU - McDonald, Patrick
AU - Int Infant Hydrocephalus
AU - Study
JO - Child's Nervous System
PY - 2020
VL - 36
TODO - 7
SP - 1407-1414
PB - Springer-Verlag
SN - 0256-7040, 1433-0350
TODO - 10.1007/s00381-020-04503-y
TODO - International Infant Hydrocephalus Study; Infant hydrocephalus;
Endoscopic third ventriculostomy; Shunt
TODO - Purpose The craniometrics of head circumference (HC) and ventricular
size are part of the clinical assessment of infants with hydrocephalus
and are often utilized in conjunction with other clinical and
radiological parameters to determine the success of treatment. We aimed
to assess the effect of endoscopic third ventriculostomy (ETV) and
shunting on craniometric measurements during the follow-up of a cohort
of infants with symptomatic triventricular hydrocephalus secondary to
aqueductal stenosis. Methods We performed a post hoc analysis of data
from the International Infant Hydrocephalus Study (IIHS)-a prospective,
multicenter study of infants (< 24 months old) with hydrocephalus from
aqueductal stenosis who were treated with either an ETV or shunt. During
various stages of a 5-year follow-up period, the following craniometrics
were measured: HC, HC centile, HCz-score, and frontal-occipital horn
ratio (FOR). Data were compared in an analysis of covariance, adjusting
for baseline variables including age at surgery and sex. Results Of 158
enrolled patients, 115 underwent an ETV, while 43 received a shunt. Both
procedures led to improvements in the mean HC centile position
andz-score, a trend which continued until the 5-year assessment point. A
similar trend was noted for FOR which was measured at 12 months and 3
years following initial treatment. Although the values were consistently
higher for ETV compared with shunt, the differences in HC value,
centile, andz-score were not significant. ETV was associated with a
significantly higher FOR compared with shunting at 12 months (0.52 vs
0.44;p = 0.002) and 3 years (0.46 vs 0.38;p = 0.03) of follow-up.
Conclusion ETV and shunting led to improvements in HC centile,z-score,
and FOR measurements during long-term follow-up of infants with
hydrocephalus secondary to aqueductal stenosis. Head size did not
significantly differ between the treatment groups during follow-up,
however ventricle size was greater in those undergoing ETV when measured
at 1 and 3 years following treatment.
ER -