TY - JOUR
TI - Percutaneous Microwave Ablation of Liver Lesions: Differences on the
Sphericity Index of the Ablation Zone between Cirrhotic and Healthy
Liver Parenchyma
AU - Tsochatzis, Athanasios
AU - Mazioti, Argyro
AU - Iliadis, Georgios and
AU - Velonakis, Georgios
AU - Efthymiou, Evgenia
AU - Kelekis, Alexis and
AU - Kelekis, Nikolaos
AU - Filippiadis, Dimitrios
JO - DIAGNOSTIC ONCOLOGY
PY - 2021
VL - 11
TODO - 4
SP - null
PB - MDPI
SN - null
TODO - 10.3390/diagnostics11040655
TODO - microwave ablation; liver; fibrosis; cirrhosis
TODO - To compare different parameters of the sphericity index of the ablation
zone following microwave ablation (MWA) on cirrhotic- and healthy-liver
parenchyma in a series of patients treated with the same MWA system.
Institutional database research identified 46 patients (77 lesions) who
underwent MWA. “Cirrhotic liver group” (CLG) included 35
hepatocellular carcinoma lesions; “healthy liver group” (HLG)
included 42 metastatic lesions. The long axis (LAD), short axis 1
(SAD-1) and 2 (SAD-2), the mean SAD-1 and SAD-2 (mSAD) diameter (in mm)
and the mean sphericity (mSPH) index of the ablation zones were
evaluated for each treated lesion in both groups from baseline to
follow-up. A mixed model analysis of variance reported significant main
effect of group on SAD-1 (p = 0.023), SAD-2 (p = 0.010) and mSAD (p =
0.010), with HLG showing lower values compared to CLG. No differences
were detected on the LAD (p(FDR) = 0.089; d = 0.45), and mSPH (p(FDR) =
0.148, d = 0.40) between the two groups. However, a significant main
effect of time was found on LAD (p < 0.001), SAD-1 (p < 0.001), SAD-2 (p
< 0.001) and mSAD (p < 0.001), with decreased values in all indices at
follow-up compared to baseline. A significant group by time interaction
was observed on mSPH (p = 0.044); HLG had significantly lower mSPH at
follow-up where CLG did not show any significant change. Our findings
indicate that although in cirrhotic liver short axis diameter of the MWA
zone seems to be significantly longer, this has no effect on the
sphericity index which showed no significant difference between
cirrhotic vs. healthy liver lesions. On the contrary, on one month
follow-up ablation zones tend to become significant more ellipsoid in
healthy whilst remains stable in cirrhotic liver.
ER -