TY - JOUR
TI - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN
Study Rationale and Protocol
AU - Bruno, Rosa Maria
AU - Spronck, Bart
AU - Hametner, Bernhard
AU - Hughes,
AU - Alun
AU - Lacolley, Patrick
AU - Mayer, Christopher C.
AU - Muiesan, Maria
AU - Lorenza
AU - Rajkumar, Chakravarthi
AU - Terentes-Printzios, Dimitrios and
AU - Weber, Thomas
AU - Hansen, Tine Willum
AU - Boutouyrie, Pierre
AU - ARTERY
AU - Soc
JO - Artery Research
PY - 2021
VL - 27
TODO - 2
SP - 59-68
PB - BMC
SN - 1872-9312
TODO - 10.2991/artres.k.201124.001
TODO - COVID-19; coronavirus; inflammation; vascular ageing; arterial stiffness
TODO - In December 2019, an outbreak of pneumonia caused by a novel Coronavirus
(COVID-19) spread rapidly worldwide. Although the clinical
manifestations of COVID-19 are dominated by respiratory symptoms, the
cardiovascular system is extensively affected at multiple levels. Due to
the unprecedented consequences of the COVID-19 pandemic, the ARTERY
society decided to launch the Covid-19 effects on ARTErial StIffness and
vascular AgeiNg (CARTESIAN) study - the first international multicentre
study into the effects of COVID-19 on non-invasive biomarkers of
vascular ageing. The main study objective is to evaluate the presence of
Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection.
Secondary objectives are to study the effect of COVID-19 disease
severity on EVA, to investigate the role of psychosocial factors in
COVID-19 induced EVA, and to investigate the potential modifying effect
of comorbidities and chronic treatments. In the CARTESIAN study, a broad
array of cardiovascular measurements, including carotid-femoral pulse
wave velocity, central blood pressure, carotid ultrasound, brachial
flow-mediated dilatation, will be performed. To date, 43 centres from 21
countries have agreed to participate, with an expected study population
of >2500 individuals. To our knowledge, CARTESIAN will be the first
study to provide insight into the relationship between COVID-19, its
severity, and early vascular ageing in a large cohort, potentially
enabling future care and diagnostics to be more focused on the most
vulnerable. (C) 2020 The Authors. Publishing services by Atlantis Press
International B.V.
ER -