TY - JOUR
TI - Long-term exposure to low-level air pollution and incidence of asthma:
the ELAPSE project
AU - Liu, Shuo
AU - Jorgensen, Jeanette Therming
AU - Ljungman, Petter and
AU - Pershagen, Goran
AU - Bellander, Tom
AU - Leander, Karin
AU - Magnusson,
AU - Patrik K. E.
AU - Rizzuto, Debora
AU - Hvidtfeldt, Ulla A.
AU - Nielsen,
AU - Ole Raaschou
AU - Wolf, Kathrin
AU - Hoffmann, Barbara
AU - Brnekree, Bert
AU - and Strak, Maciej
AU - Chen, Jie
AU - Mehta, Amar
AU - Atkinson, Richard W.
AU - and Bauwelrick, Mariska
AU - Varraso, Raphaelle
AU - Boutron-Ruault,
AU - Marie-Christine
AU - Brandt, Jorgen
AU - Cesaroni, Giulia
AU - Forastiere,
AU - Francesco
AU - Fecht, Daniela
AU - Gulliver, John
AU - Herte, Ole
AU - de
AU - Hoogh, Kees
AU - Janssen, Nicole A. H.
AU - Katsouyanni, Klea
AU - Ketzel,
AU - Matthias
AU - Klompmaker, Jochem O.
AU - Nagel, Gabriele
AU - Oftedal,
AU - Bente
AU - Peters, Annette
AU - Tjonneland, Anne
AU - Rodopoulou, Sophia P.
AU - and Samoli, Evangelia
AU - Kristoffersen, Doris Tove
AU - Sigsgaard,
AU - Torben
AU - Stafoggia, Massimo
AU - Vienneau, Danielle
AU - Weinmayr,
AU - Gudrun
AU - Hoek, Gerard
AU - Andersen, Zorana Jovanovic
JO - The European respiratory journal
PY - 2021
VL - 57
TODO - 6
SP - null
PB - EUROPEAN RESPIRATORY SOC JOURNALS LTD
SN - null
TODO - 10.1183/13993003.030992020
TODO - null
TODO - Background: Long-term exposure to ambient air pollution has been linked
to childhood-onset asthma, although evidence is still insufficient.
Within the multicentre project Effects of Low-Level Air Pollution: A
Study in Europe (ELAPSE), we examined the associations of long-term
exposures to particulate matter with a diameter <2.5 mu m (PM2.5),
nitrogen dioxide (NO2) and black carbon (BC) with asthma incidence in
adults.
Methods: We pooled data from three cohorts in Denmark and Sweden with
information on asthma hospital diagnoses. The average concentrations of
air pollutants in 2010 were modelled by hybrid land-use regression
models at participants’ baseline residential addresses. Associations of
air pollution exposures with asthma incidence were explored with Cox
proportional hazard models, adjusting for potential confounders.
Results: Of 98326 participants, 1965 developed asthma during a mean
follow-up of 16.6 years. We observed associations in fully adjusted
models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 mu g.m(-3)
for PM2.5, 1.17 (95% CI 1.10-1.25) per 10 mu g.m(-3) for NO2 and 1.15
(95% CI 1.08-1.23) per 0.5 x 10(-5) m(-1) for BC. Hazard ratios were
larger in cohort subsets with exposure levels below the European Union
and US limit values and possibly World Health Organization guidelines
for PM2.5 and NO2. NO 2 and BC estimates remained unchanged in
two-pollutant models with PM2.5, whereas PM2.5 estimates were attenuated
to unity. The concentration-response curves showed no evidence of a
threshold.
Conclusions: Long-term exposure to air pollution, especially from fossil
fuel combustion sources such as motorised traffic, was associated with
adult-onset asthma, even at levels below the current limit values.
ER -