TY - JOUR
TI - SLICC-Frailty Index is independently associated with impaired physical function, activities of daily living, and quality of life measures.
AU - Keramiotou, Kyriaki
AU - Anagnostou, Christos
AU - Konstantonis, George
AU - Fragiadaki, Kalliopi
AU - Kataxaki, Evangelia
AU - Sfikakis, Petros P.
AU - Tektonidou, Maria G.
JO - Rheumatology (Oxford, England)
PY - 2022
VL - null
TODO - null
SP - keac001
PB - 
SN - null
TODO - 10.1093/rheumatology/keac001
TODO - Systemic lupus erythematosus, activities of daily living, health-related quality of life, physical function, Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI)
TODO - OBJECTIVE: The Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) was developed to assess health deficits including disease activity, organ  damage, comorbidities and functional status. We examined any relationship between  SLICC-FI and objective physical function measures, activities of daily living (ADL)  performance, and quality of life in Systemic Lupus Erythematosus (SLE). METHODS:  SLICC-FI was estimated using data from patient files and patient-reported  questionnaires. Jamar Dynamometer, pinch gauge and Purdue pegboard test measured  grip strength, pinch strength and dexterity, respectively. ADL performance was  assessed by the Disabilities of Arm, Shoulder and Hand (DASH) questionnaire, and  Health Assessment Questionnaire (HAQ). Quality of life was evaluated by LupusQol  questionnaire. RESULTS: This cross-sectional study included 240 SLE patients (90\%  female, mean (SD) age: 47.63 (13.01), median (IQR) disease duration: 9 (4-16). Mean  (SD) SLICC-FI was 0.09 (0.06). Forty-three (17.9\%) patients were classified as  robust, 105 (43.8\%) as relatively less fit, 77 (32.1\%) as least fit, and 15 (6.2\%)  as frail. In univariate analysis, SLICC-FI was significantly associated with DASH  and HAQ with an inverse association with grip strength, pinch strength, and all  purdue scores (all p {\textless} 0.001). A negative correlation was found between SLICC-FI  score and all LupusQoL domain scores (all p {\textless} 0.001). All associations remained  statistically significant in multivariate regression analysis, after adjustment for  age, disease duration, SLEDAI-2K, SLICC, immunosuppressives, corticosteroids and  Charlson score. CONCLUSION: SLICC-FI is independently associated with poor physical  function and ADL performance and impaired quality of life and may help to identify  patients in need for additional interventions beyond routine care.
ER -