TY - JOUR TI - Off-label intravenous thrombolysis for early recurrent brain embolism associated with aortic arch thrombus. AU - Koutroulou, Ioanna AU - Tsivgoulis, Georgios AU - Rafailidis, Vasileios AU - Psoma, Elissavet AU - Kouskouras, Konstantinos AU - Fotiadis, Panagiotis AU - Grigoriadis, Nikolaos AU - Karapanayiotides, Theodoros JO - Neurological research and practice PY - 2021 VL - 3 TODO - 1 SP - 4 PB - SN - null TODO - 10.1186/s42466-021-00103-6 TODO - Aortic arch thrombus, Brain embolism, Off-label thrombolysis, Stroke TODO - Safety data of intravenous thrombolysis (IVT) in presence of aortic arch thrombus is scant. Furthermore, IVT is debatable in patients with prior recent stroke. We present a 51-year-old woman with recurrent major infarction 5 days after a minor left MCA territory stroke. She had a floating aortic arch thrombus and she was treated safely and effectively with off-label IVT. Patients with small infarct volumes and mild/no residual neurological deficits after an initial stroke might be considered for IVT in case of early recurrence. IVT may be reasonable in a context of acute severely disabling stroke associated with aortic arch thrombus. ER -