TY - JOUR
TI - SARS-CoV-2 adipose tissue infection and hyperglycemia: A further step towards the understanding of severe COVID-19.
AU - Tsilingiris, Dimitrios
AU - Dalamaga, Maria
AU - Liu, Junli
JO - Metabolism open
PY - 2022
VL - 13
TODO - null
SP - 100163
PB - 
SN - null
TODO - 10.1016/j.metop.2022.100163
TODO - COVID-19, SARS-CoV-2, Adipokine, Hyperglycemia, Insulin resistance, Adiponectin, Adipose tissue
TODO - Numerous studies have highlighted the prognostic significance of hyperglycemia in the outcomes of SARS-CoV-2 infection. A number of mechanisms have been proposed as  potential drivers of this association, which were, however, up until recently based  rather on speculation than on investigational evidence. It has been recently come to  light that the development of insulin resistance in the frame of COVID-19 is likely  the driving force behind the development of overt hyperglycemia. This results  through the infectious insult of the adipose tissue, and is observed in conjunction  with aberrant adipokine secretion by host adipocytes, such as decreased adiponectin,  as well as a switch towards an antiviral immune secretory profile. These data could  have a considerable relevance not only for the management of hyperglycemia in the  course of the infection but also for the overall understanding of the pathogenesis  of severe COVID-19.
ER -