TY - JOUR
TI - Does Age Matter in Psoriatic Arthritis? A Narrative Review.
AU - Fragoulis, George E.
AU - Nikiphorou, Elena
AU - McInnes, Iain B.
AU - Siebert, Stefan
JO - The Internet Journal of Rheumatology
PY - 2021
VL - null
TODO - null
SP - jrheum.210349
PB - 
SN - 1528-8412
TODO - 10.3899/jrheum.210349
TODO - null
TODO - Psoriatic arthritis (PsA) affects approximately 0.8% of the general population. PsA, together with psoriasis (PsO), constitute psoriatic disease (PsD). Comorbidities  play an important role in the clinical expression and treatment of PsD. Aging adds  another level of complexity, partly because age directly accrues increasing risk of  comorbidities, but also because of its complex interactions with several factors  such as depression and social determinants. Aging seems to have a "paradoxical  association" with cardiovascular comorbidities, for which the relative risk is more  pronounced in younger patients with PsD. It also affects treatment decisions and  treatment response in patients with PsD. Finally, there is convincing evidence that  there are clinical, genetic, and histopathological differences between early- and  late-onset PsA and PsO. Herein, we review the effect of age in patients with PsD,  with a focus on PsA, highlighting the need to consider this factor in routine  clinical practice as well as in research.
ER -