TY - JOUR
TI - A Role for Sox2 in the Adult Cerebellum.
AU - Mandalos, Nikolaos Panagiotis
AU - Karampelas, Ioannis
AU - Saridaki, Marannia
AU - McKay, Ronald D. G.
AU - Cohen, Mark L.
AU - Remboutsika, Eumorphia
JO - Journal of stem cell research & therapy
PY - 2018
VL - 8
TODO - 7
SP - 433
PB - 
SN - null
TODO - 10.4172/2157-7633.1000433
TODO - *Neurodegeneration, *Development, *Differentiation, *Neural progenitor cells, *Neural stem cells, *Neurogenesis, *Sox genes
TODO - The cerebellum, a derivative of the hindbrain, plays a crucial role in balance and posture as well as in higher cognitive and locomotive processes. Cerebellar  development is initiated during the segmental phase of hindbrain formation. Here, we  describe the phenotype, of a single surviving adult conditional mouse mutant mouse,  in which Sox2 function is ablated in embryonic radial glial cells by means of  hGFAP-CRE. The single Sox2(RGINV/mosaic) adult mutant mouse displays motor  disability, microsomia, reduced Central Nervous System (CNS) size and cerebellar  defects associated with human genetically related congenital abnormalities.
ER -