TY - JOUR
TI - Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
AU - Vrachatis, D.A.
AU - Papathanasiou, K.A.
AU - Kazantzis, D.
AU - Sanz-Sánchez, J.
AU - Giotaki, S.G.
AU - Raisakis, K.
AU - Kaoukis, A.
AU - Kossyvakis, C.
AU - Deftereos, G.
AU - Reimers, B.
AU - Avramides, D.
AU - Siasos, G.
AU - Cleman, M.
AU - Giannopoulos, G.
AU - Lansky, A.
AU - Deftereos, S.
JO - DIAGNOSTIC ONCOLOGY
PY - 2022
VL - 12
TODO - 5
SP - null
PB - MDPI
SN - null
TODO - 10.3390/diagnostics12051026
TODO - null
TODO - Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
ER -