TY - JOUR TI - A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut! AU - Kasti, A. AU - Petsis, K. AU - Lambrinou, S. AU - Katsas, K. AU - Nikolaki, M. AU - Papanikolaou, I.S. AU - Hatziagelaki, E. AU - Triantafyllou, K. JO - Microorganisms PY - 2022 VL - 10 TODO - 4 SP - null PB - MDPI SN - null TODO - 10.3390/microorganisms10040751 TODO - null TODO - Among other factors, food intolerance is cardinal in triggering irritable bowel syndrome (IBS) symptoms in a significant percentage of patients. As a result, specific dietary patterns are the first-line therapeutic approach. The low-FODMAP diet (LFD) is gaining ground as the most welldocumented diet intervention that significantly reduces IBS symptoms. Though the LFD improves symptoms, the diet’s impact on intestinal low-grade inflammation, one of the cardinal mechanisms contributing to symptom development, remains doubtful. On the other hand, the Mediterranean diet (MedDiet) is recommended for chronic low-grade inflammation-related diseases because of its anti-inflammatory properties, derived predominantly from olive oil and phenolic compounds. Thus far, the role of a modified LFD, enriched with the MedDiet’s anti-inflammatory components, has not been evaluated in IBS patients. This review aims to examine the hypothesis of a potential combination of the immunomodulatory effects of the MedDiet with the LFD to improve IBS symptoms. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. ER -