TY - JOUR
TI - Opioid-Free Anesthesia and Postoperative Cognitive Dysfunction After Minor Urological Surgery: A Case Series Study
AU - Efstathiou, G.
AU - Batistaki, C.
AU - Soulioti, E.
AU - Roungeris, L.
AU - Matsota, P.
JO - Anesthesiology and Pain Medicine
PY - 2022
VL - 12
TODO - 1
SP - null
PB - Kowsar Medical Institute
SN - null
TODO - 10.5812/aapm.122094
TODO - dexaton;  dexmedetomidine;  ketamina molteni;  ketamine;  lidocaine;  paracetamol;  propofol;  ranitidine;  rocuronium, adult;  aged;  anesthesia;  anesthesiologist;  Article;  bispectral index;  bladder tumor;  case report;  clinical article;  continuous infusion;  drug withdrawal;  education;  extubation;  female;  human;  lithotripsy;  male;  Mini Mental State Examination;  opioid free anesthesia;  perioperative period;  postoperative cognitive dysfunction;  prospective study;  transurethral resection;  urologic surgery
TODO - Background: Postoperative cognitive dysfunction (POCD) is a complication that mainly occurs in adult patients and refers to a new-onset decline in cognitive function after anesthesia and surgery. The literature lacks evidence regarding opioid-free anesthesia and its impact on mental function postoperatively. Objectives: The effect of opioid-free anesthesia on POCD following urological surgery has not been previously reported. Accord-ingly, we present a case series of 15 adult patients undergoing transurethral urological surgery under general anesthesia using an opioid-free protocol with dexmedetomidine, ketamine, and lidocaine. Methods: Patients that underwent simple transurethral elective urological procedures under general opioid-free anesthesia were included. This case series is part of a prospective clinical study regarding opioid-free anesthesia and served as a pilot sample. The mini-mental state examination (MMSE) test, performed preoperatively and 12 hours postoperatively, was applied to assess POCD. Results: Fifteen patients with a mean age of 68 years old were included in the study. The opioid-free protocol was associated with non-statistically significant changes of the MMSE test after minor urological procedures. Conclusions: In our study, an opioid-free protocol of general anesthesia, using a mixture of dexmedetomidine, ketamine, and lido-caine, did not seem to have a negative impact on postoperative cognitive function in patients undergoing transurethral urological surgery. Further studies specifically designed to identify this effect are certainly required to further prove such an effect. © 2022, Author(s).
ER -