TY - JOUR
TI - Trained immunity in viral infections, Alzheimer's disease and multiple sclerosis: A convergence in type I interferon signalling and IFNβ-1a
AU - Vavougios, G.D.
AU - Mavridis, T.
AU - Artemiadis, A.
AU - Krogfelt, K.A.
AU - Hadjigeorgiou, G.
JO - Biochimica et Biophysica Acta.  Molecular Basis of Disease
PY - 2022
VL - 1868
TODO - 9
SP - null
PB - Elsevier B.V.
SN - 0925-4439
TODO - 10.1016/j.bbadis.2022.166430
TODO - null
TODO - Type I interferon (IFN-I) signalling represents a major target for modulation in a virus' bid for latency. IFN-I perturbations are also present in such as Alzheimer's disease (AD) and multiple sclerosis (MS), where viral infections are known to increase symptomatic burden. IFN-I modulation such as via IFNβ-1a, an established MS treatment, has been researched to a limited extent to both AD and COVID-19. In this mini review, we present emerging research on trained immunity as a pathogenetic basis for Alzheimer's disease and the emerging context for IFNβ-1a repositioning, via mechanisms shared with multiple sclerosis and induced by viral infections. © 2022 Elsevier B.V.
ER -