TY - JOUR
TI - Dose-dense sequential adjuvant chemotherapy in the trastuzumab era: final long-term results of the Hellenic Cooperative Oncology Group Phase III HE10/05 Trial
AU - Zagouri, F.
AU - Koliou, G.-A.
AU - Dimitrakopoulos, F.
AU - Papadimitriou, C.
AU - Binas, I.
AU - Koutras, A.
AU - Papakostas, P.
AU - Markopoulos, C.
AU - Venizelos, V.
AU - Xepapadakis, G.
AU - Andrikopoulou, Α.
AU - Karanikiotis, C.
AU - Psyrri, A.
AU - Bafaloukos, D.
AU - Kosmidis, P.
AU - Aravantinos, G.
AU - Res, E.
AU - Mauri, D.
AU - Koumarianou, A.
AU - Petraki, K.
AU - Tsipoura, A.
AU - Pectasides, D.
AU - Gogas, H.
AU - Fountzilas, G.
JO - British Journal of Cancer
PY - 2022
VL - null
TODO - null
SP - null
PB - Springer Nature BV
SN - 0007-0920, 1532-1827
TODO - 10.1038/s41416-022-01846-y
TODO - null
TODO - Background: Dose-dense sequential chemotherapy with anthracyclines and taxanes achieved an 18% reduction of recurrence risk in early breast cancer (BC). The optimal chemotherapy schedule and interval between cycles remain under investigation. Methods: Overall, 990 patients were randomised to receive either three cycles of epirubicin (E, 110 mg/m2) every 2 weeks followed by 3 cycles of paclitaxel (T, 200 mg/m2) every 2 weeks followed by three cycles of intensified CMF (Control Arm A, E-T-CMF) that was previously used in BC or three cycles of epirubicin followed by three cycles of CMF followed by nine consecutive weekly cycles of docetaxel (wD) 35 mg/m2 (Arm B, E-CMF-wD) or nine consecutive weekly cycles of paclitaxel (wT) 80 mg/m2 (Arm C, E-CMF-wT). Trastuzumab was administered for HER2-positive disease. Results: At a median follow-up of 13.3 years, 330 disease-free survival (DFS) events (33.3%) were reported. DFS and overall survival (OS) did not differ between patients in the combined B and C arms versus arm A either in the entire cohort (HR = 0.90, P = 0.38 and HR = 0.85, P = 0.20) or among trastuzumab-treated patients (HR = 0.69, P = 0.13 and HR = 0.67, P = 0.13). Thirty-four patients (3.4%) developed secondary neoplasms. Conclusions: Overall, no significant differences in survival were found amongst the studied regimens after a long-term observational period. Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12610000151033. © 2022, The Author(s), under exclusive licence to Springer Nature Limited.
ER -