TY - JOUR
TI - A Rare Case of Primary Carcinosarcoma of the Breast
AU - Kiakou, M.
AU - Tolia, M.
AU - Koufopoulos, N.
AU - Tsapakidis, K.
AU - Arvanitou, E.
AU - Konstantinos, G.
AU - Charalambakis, N.
AU - Nikolaou, M.
AU - Matthaios, D.
AU - Tsoukalas, N.
JO - Forum of Clinical Oncology
PY - 2023
VL - null
TODO - null
SP - null
PB - De Gruyter Open Ltd
SN - 1792-345X, 1792-362X
TODO - 10.2478/fco-2022-0006
TODO - null
TODO - Breast carcinosarcoma is a rare malignancy accounting for approximately 0.08-0.2% of all breast tumours. It is a type of metaplastic mammary carcinoma displaying biphasic differentiation with epithelial and mesenchymal cellular characteristics with probable derivation from myoepithelial cells. A 65-year-old woman presented to our hospital with a two-month history of a rapidly growing mass in her left breast. Neither her medical nor family history was positive for malignancies. Subsequently, she underwent a fine needle aspiration, which was positive for adenocarcinoma, followed by a lumpectomy with axillary lymph node dissection. The histology revealed an undifferentiated neoplasm and the immunohistochemical cell staining was positive for pan-cytokeratin, SMA, Vimentin, and S-100, suggesting the diagnosis of breast carcinosarcoma with a triple-negative immunophenotype. There was no evidence of metastasis except for a positive lymph node, indicating a stage IIIA disease. Thus, she received adjuvant chemo-radiotherapy. However, 16 months later, she presented with metastatic disease, and unfortunately, she died 4 months later due to a systemic infection. Aggressive behavior, higher staging, chemoresistance, and higher proportion of triple negative breast cancer seem to be the main characteristics of breast carcinosarcoma, which is recognised as a separate entity from common invasive ductal carcinoma, with significantly worse clinical outcomes. © 2023 Maria Kiakou et al., published by Sciendo 2023.
ER -