TY - JOUR
TI - Comparative effectiveness and durability of COVID-19 vaccination against death and severe disease in an ongoing nationwide mass vaccination campaign
AU - Lytras, T.
AU - Kontopidou, F.
AU - Lambrou, A.
AU - Tsiodras, S.
JO - Journal of Medical Virology
PY - 2022
VL - 94
TODO - 10
SP - 5044-5050
PB - John Wiley and Sons Inc
SN - 0146-6615, 1096-9071
TODO - 10.1002/jmv.27934
TODO - elasomeran;  SARS-CoV-2 vaccine;  tozinameran;  vaxzevria, Article;  clinical feature;  comparative effectiveness;  controlled study;  coronavirus disease 2019;  disease registry;  disease severity;  disease surveillance;  Greece;  human;  immunogenicity;  intubation;  morbidity;  mortality rate;  public health campaign;  vaccination coverage;  virus strain;  epidemiology;  prevention and control;  preventive health service;  vaccination, Ad26COVS1;  BNT162 Vaccine;  ChAdOx1 nCoV-19;  COVID-19;  COVID-19 Vaccines;  Humans;  Immunization Programs;  SARS-CoV-2;  Vaccination
TODO - As national coronavirus disease 2019 (COVID-19) mass vaccination campaigns are rolled out, monitoring real-world Vaccine Effectiveness (VE) and its durability is essential. We aimed to estimate COVID-19 VE against severe disease and death in the Greek population, for all vaccines currently in use. Nationwide active surveillance and vaccination registry data during January–December 2021 were used to estimate VE via quasi-Poisson regression, adjusted for age and calendar time. Interaction terms were included to assess VE by age group, against the “delta” severe acute respiratory syndrome coronavirus 2 variant and waning of VE over time. Two doses of BNT162b2, mRNA-1273, or ChAdOx1 nCov-19 vaccines offered very high (>90%) VE against both intubation and death across all age groups, similar against both “delta” and previous variants, with one-dose Ad26.COV2.S slightly lower. VE waned over time but remained >80% at 6 months, and three doses increased VE again to near 100%. Vaccination prevented an estimated 19 691 COVID-19 deaths (95% confidence interval: 18 890–20 788) over the study period. All approved vaccines offer strong and also durable protection against COVID-19 severe disease and death. Every effort should be made to vaccinate the population with at least two doses, to reduce the mortality and morbidity impact of the pandemic. © 2022 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
ER -