TY - JOUR
TI - The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization.
AU - Paraskevi Tsiolaki
AU - Stavros Hamodrakas
AU - Vassiliki Iconomidou
JO - FEBS Letters
PY - 2015
VL - 589
TODO - 1
SP - 159-164
PB - Wiley
SN - 0014-5793
TODO - null
TODO - Human cystatin C, Hereditary Cystatin C Amyloid Angiopathy, Alzheimer’s disease, 3D-domain swapping,  ‘Aggregation-prone’ pentapeptide LQVVR, Amyloid fibrils
TODO - Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC
consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological
conditions it forms amyloid fibrils in brain arteries of young adults. An ‘aggregation-prone’ pentapeptide
(47LQVVR51) was located within the HCC sequence using AmylPred, an ‘aggregation-prone’
peptide prediction algorithm developed in our lab. This peptide was synthesized and self-assembled
into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, Attenuated Total
Reflectance Fourier-Transform Spectroscopy and Congo red staining studies reveal. Thus, the
47-LQVVR-51 peptide seems to have an important role in HCC fibrillization.
ER -