TY - JOUR
TI - Diorganotin(IV) complexes of dipeptides containing the
alpha-aminoisobutyryl residue (Aib): Preparation, structural
characterization, antibacterial and antiproliferative activities of
[(n-Bu)(2)Sn(H-L-1)] (LH = H-Aib-L-Leu-OH, H-Aib-L-Ala-OH)
AU - Eugenia Katsoulakou
AU - Manolis Tiliakos
AU - Giannis Papaefstathiou
AU - Aris Terzis
AU - Catherine Raptopoulou
AU - George Geromichalos
AU - Konstantinos Papazisis
AU - Rigini Papi
AU - Anastasia Pantazaki
AU - Dimitris Kyriakidis
AU - Paul Cordopatis
AU - Evy Manessi-Zoupa
JO - Journal of Inorganic Biochemistry
PY - 2008
VL - 102
TODO - 7
SP - 1397--1405
PB - ELSEVIER BV
SN - 0162-0134
TODO - 10.1016/j.jinorgbio.2008.01.001
TODO - null
TODO - Two new organotin(IV) complexes with dianionic dipeptides containing the
alpha-aminoisobutyryl residue (Aib) as ligands are described. The solid
complexes [(n-Bu)(2)Sn(H-1LA)]center dot 2MeOH (1.2MeOH) (LAH =
H-Aib-L-Leu-OH) and [(n-Bu)(2)Sn(H-L-1(B))]. MeOH (2 center dot MeOH)
(LBH = H-Aib-L-Ala-OH) have been isolated and characterized by
single-crystal X-ray crystallography and spectroscopic techniques
(H-1L2- is the dianionic form of the corresponding dipeptide). Complexes
1.2MeOH and 2 center dot MeOH are monomeric with similar molecular
structures. The doubly deprotonated dipeptide behaves as a N(amino),
N(peptide), O(carboxylate) ligand and binds to the Sn-IV atom. The
five-coordinate metal ion has a distorted trigonal bipyramidal geometry.
A different network of intermolecular hydrogen bonds in each compound
results in very dissimilar supramolecular features. The IR, far-IR,
Raman and Sn-119 NMR data are discussed in terms of the nature of
bonding and known structures. The antibacterial and antiproliferative
activities as well as the effect of the new compounds on pDNA were
examined. Complexes I and 2 are active against the gram-positive
bacteria Bacillus subtilis and Bacillus cereus. The IC50 values reveal
that the two compounds express promising cytotoxic activity in vitro
against a series of cell lines. (c) 2008 Elsevier Inc. All rights
reserved.
ER -