@article{2935036,
    title = "{Synthesis of N4-aryl-$\beta$-d-glucopyranosylcytosines: a methodology study}",
    author = "Michael Mamais and Virginia Kouloumoundra and Eugenia Smyrli and Paschalis Grammatopoulos and Evangelia D. Chrysina and Thanasis Gimisis",
    journal = "TETRAHEDRON LETTERS",
    year = "2015",
    volume = "56",
    number = "41",
    pages = "5549--5552",
    publisher = "ELSEVIER BV",
    issn = "0040-4039",
    doi = "10.1016/j.tetlet.2015.08.037",
    keywords = "Microwaves,N4,[Arylamines",
    abstract = "{\textcopyright} 2015 Elsevier Ltd. All rights reserved.A number of leaving groups, including arylsulfonates, triazoles, 3-nitrotriazoles, and tetrazoles, have been studied for the substitution reaction by aryl and alkyl amines at the 4-position of $\beta$-D-glucopyranosyluracils. Examination of the stability, ease of purification and reactivity in the substitution reaction led to a number of optimized conditions with the most convenient involving substitution of triazole derivatives under microwave conditions in the presence of silica gel. Under these conditions, a number of N4-aryl-substituted $\beta$-D-glucopyranosylcytosines were prepared as potential inhibitors of glycogen phosphorylase, a molecular target for type-2 diabetes mellitus."
}