TY - JOUR
TI - Complexation-Driven Mutarotation in Poly(l-proline) Block Copolypeptides
AU - Manos Gkikas
AU - Johannes S. Haataja
AU - Janne Ruokolainen
AU - Hermis Iatrou
AU - Nikolay Houbenov
JO - Biomacromolecules
PY - 2015
VL - 16
TODO - 11
SP - 3686--3693
PB - American Chemical Society (ACS)
SN - 1525-7797, 1526-4602
TODO - 10.1021/acs.biomac.5b01198
TODO - Amino acids;  Anionic surfactants;  Functional materials;  Hydrogen bonds;  Molecules;  Supramolecular chemistry, Biological functions;  Block copolypeptides;  Dodecylbenzenesulfonic acid;  External stimulus;  Helical conformers;  Monophosphates;  Poly(l lysine);  Supramolecular complexation, Biological materials, anionic surfactant;  deoxyguanosine phosphate;  dodecylbenzenesulfonic acid;  poly(levo lysine);  poly(levo proline);  polylysine;  polypeptide;  unclassified drug;  benzenesulfonic acid derivative;  biomaterial;  peptide;  polylysine;  polyproline;  surfactant, Article;  beta sheet;  complex formation;  conformational transition;  crystal structure;  crystallization;  cyclization;  dissolution;  hydrogen bond;  hydrophilicity;  molecular weight;  periodicity;  priority journal;  static electricity;  supramolecular chemistry;  chemistry, Benzenesulfonates;  Biocompatible Materials;  Peptides;  Polylysine;  Static Electricity;  Surface-Active Agents
TODO - Novel poly(l-lysine)-block-poly(l-proline) (PLL-b-PLP)-based materials with all PLP helical conformers, i.e., PLP II and the rare PLP I are here reported. Electrostatic supramolecular complexation of the adjacent cationic PLL with anionic molecules bearing DNA analogue H-bonding functionalities, such as deoxyguanosine monophosphate (dGMP), preserves the extended PLP II helix, and the complexed molecule is locked and held in position by orthogonal shape-persistent hydrogen-bonded dGMP ribbons and their extended π-stacking. The branched anionic surfactant dodecylbenzenesulfonic acid (DBSA) on the other hand, introduces periodicity frustration and interlayer plasticization, leading to a reversed mutarotation to the more compact PLP I helix by complexation, without external stimuli, and is here reported for the first time. We foresee that our findings can be used as a platform for novel molecularly adaptive functional materials, and could possibly give insight in many proline-related transmembrane biological functions. © 2015 American Chemical Society.
ER -