@article{3149478,
    title = "MeDALL (Mechanisms of the Development of ALLergy): an integrated
approach from phenotypes to systems medicine",
    author = "Bousquet, J. and Anto, J. and Auffray, C. and Akdis, M. and and Cambon-Thomsen, A. and Keil, T. and Haahtela, T. and Lambrecht, B. N. and and Postma, D. S. and Sunyer, J. and Valenta, R. and Akdis, C. A. and and Annesi-Maesano, I. and Arno, A. and Bachert, C. and Ballester, F. and and Basagana, X. and Baumgartner, U. and Bindslev-Jensen, C. and Brunekreef, and B. and Carlsen, K. H. and Chatzi, L. and Crameri, R. and Eveno, E. and and Forastiere, F. and Garcia-Aymerich, J. and Guerra, S. and Hammad, H. and and Heinrich, J. and Hirsch, D. and Jacquemin, B. and Kauffmann, F. and and Kerkhof, M. and Kogevinas, M. and Koppelman, G. H. and Kowalski, M. L. and and Lau, S. and Lodrup-Carlsen, K. C. and Lopez-Botet, M. and Lotvall, and J. and Lupinek, C. and Maier, D. and Makela, M. J. and Martinez, F. D. and and Mestres, J. and Momas, I. and Nawijn, M. C. and Neubauer, A. and and Oddie, S. and Palkonen, S. and Pin, I. and Pison, C. and Rance, F. and and Reitamo, S. and Rial-Sebbag, E. and Salapatas, M. and Siroux, V. and and Smagghe, D. and Torrent, M. and Toskala, E. and van Cauwenberge, P. and and van Oosterhout, A. J. M. and Varraso, R. and von Hertzen, L. and and Wickman, M. and Wijmenga, C. and Worm, M. and Wright, J. and Zuberbier, and T.",
    journal = "Clinical and Experimental Allergy",
    year = "2011",
    volume = "66",
    number = "5",
    pages = "596-604",
    publisher = "Wiley",
    doi = "10.1111/j.1398-9995.2010.02534.x",
    keywords = "allergy; early diagnosis; epigenetics; framework programme 7; IgE;
mechanisms; mechanisms of the development of allergy; prevention;
proteomics; systems medicine; transcriptomics",
    abstract = "P>The origin of the epidemic of IgE-associated (allergic) diseases is
unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7
European Union project (No. 264357), aims to generate novel knowledge on
the mechanisms of initiation of allergy and to propose early diagnosis,
prevention, and targets for therapy. A novel phenotype definition and an
integrative translational approach are needed to understand how a
network of molecular and environmental factors can lead to complex
allergic diseases. A novel, stepwise, large-scale, and integrative
approach will be led by a network of complementary experts in allergy,
epidemiology, allergen biochemistry, immunology, molecular biology,
epigenetics, functional genomics, bioinformatics, computational and
systems biology. The following steps are proposed: (i) Identification of
‘classical’ and ‘novel’ phenotypes in existing birth cohorts; (ii)
Building discovery of the relevant mechanisms in IgE-associated allergic
diseases in existing longitudinal birth cohorts and Karelian children;
(iii) Validation and redefinition of classical and novel phenotypes of
IgE-associated allergic diseases; and (iv) Translational integration of
systems biology outcomes into health care, including societal aspects.
MeDALL will lead to: (i) A better understanding of allergic phenotypes,
thus expanding current knowledge of the genomic and environmental
determinants of allergic diseases in an integrative way; (ii) Novel
diagnostic tools for the early diagnosis of allergy, targets for the
development of novel treatment modalities, and prevention of allergic
diseases; (iii) Improving the health of European citizens as well as
increasing the competitiveness and boosting the innovative capacity of
Europe, while addressing global health issues and ethical issues."
}