TY - JOUR
TI - MeDALL (Mechanisms of the Development of ALLergy): an integrated
approach from phenotypes to systems medicine
AU - Bousquet, J.
AU - Anto, J.
AU - Auffray, C.
AU - Akdis, M. and
AU - Cambon-Thomsen, A.
AU - Keil, T.
AU - Haahtela, T.
AU - Lambrecht, B. N.
AU - and Postma, D. S.
AU - Sunyer, J.
AU - Valenta, R.
AU - Akdis, C. A. and
AU - Annesi-Maesano, I.
AU - Arno, A.
AU - Bachert, C.
AU - Ballester, F. and
AU - Basagana, X.
AU - Baumgartner, U.
AU - Bindslev-Jensen, C.
AU - Brunekreef,
AU - B.
AU - Carlsen, K. H.
AU - Chatzi, L.
AU - Crameri, R.
AU - Eveno, E. and
AU - Forastiere, F.
AU - Garcia-Aymerich, J.
AU - Guerra, S.
AU - Hammad, H. and
AU - Heinrich, J.
AU - Hirsch, D.
AU - Jacquemin, B.
AU - Kauffmann, F. and
AU - Kerkhof, M.
AU - Kogevinas, M.
AU - Koppelman, G. H.
AU - Kowalski, M. L.
AU - and Lau, S.
AU - Lodrup-Carlsen, K. C.
AU - Lopez-Botet, M.
AU - Lotvall,
AU - J.
AU - Lupinek, C.
AU - Maier, D.
AU - Makela, M. J.
AU - Martinez, F. D.
AU - and Mestres, J.
AU - Momas, I.
AU - Nawijn, M. C.
AU - Neubauer, A. and
AU - Oddie, S.
AU - Palkonen, S.
AU - Pin, I.
AU - Pison, C.
AU - Rance, F. and
AU - Reitamo, S.
AU - Rial-Sebbag, E.
AU - Salapatas, M.
AU - Siroux, V. and
AU - Smagghe, D.
AU - Torrent, M.
AU - Toskala, E.
AU - van Cauwenberge, P. and
AU - van Oosterhout, A. J. M.
AU - Varraso, R.
AU - von Hertzen, L. and
AU - Wickman, M.
AU - Wijmenga, C.
AU - Worm, M.
AU - Wright, J.
AU - Zuberbier,
AU - T.
JO - Clinical and Experimental Allergy
PY - 2011
VL - 66
TODO - 5
SP - 596-604
PB - Wiley
SN - null
TODO - 10.1111/j.1398-9995.2010.02534.x
TODO - allergy; early diagnosis; epigenetics; framework programme 7; IgE;
mechanisms; mechanisms of the development of allergy; prevention;
proteomics; systems medicine; transcriptomics
TODO - P>The origin of the epidemic of IgE-associated (allergic) diseases is
unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7
European Union project (No. 264357), aims to generate novel knowledge on
the mechanisms of initiation of allergy and to propose early diagnosis,
prevention, and targets for therapy. A novel phenotype definition and an
integrative translational approach are needed to understand how a
network of molecular and environmental factors can lead to complex
allergic diseases. A novel, stepwise, large-scale, and integrative
approach will be led by a network of complementary experts in allergy,
epidemiology, allergen biochemistry, immunology, molecular biology,
epigenetics, functional genomics, bioinformatics, computational and
systems biology. The following steps are proposed: (i) Identification of
‘classical’ and ‘novel’ phenotypes in existing birth cohorts; (ii)
Building discovery of the relevant mechanisms in IgE-associated allergic
diseases in existing longitudinal birth cohorts and Karelian children;
(iii) Validation and redefinition of classical and novel phenotypes of
IgE-associated allergic diseases; and (iv) Translational integration of
systems biology outcomes into health care, including societal aspects.
MeDALL will lead to: (i) A better understanding of allergic phenotypes,
thus expanding current knowledge of the genomic and environmental
determinants of allergic diseases in an integrative way; (ii) Novel
diagnostic tools for the early diagnosis of allergy, targets for the
development of novel treatment modalities, and prevention of allergic
diseases; (iii) Improving the health of European citizens as well as
increasing the competitiveness and boosting the innovative capacity of
Europe, while addressing global health issues and ethical issues.
ER -