TY - JOUR
TI - Phytochemical Investigation and Anticonvulsant Activity of Paeonia parnassica Radix
AU - Kritsanida, M.
AU - Magiatis, P.
AU - Skaltsounis, A.-L.
AU - Stables, J.P.
JO - Natural Product Communications
PY - 2007
VL - 2
TODO - 4
SP - null
PB - SAGE Publications Inc.
SN - null
TODO - 10.1177/1934578X0700200401
TODO - null
TODO - Based on traditional reports of the use of plants of the genus Paeonia in the treatment of epilepsy, we have screened extracts of the roots of three Greek Paeonia species (P. parnassica, P. mascula subsp. hellenica, P. clusii subsp. clusii) for anticonvulsant activity. This led to the identification of some interesting prophylactic anticonvulsant activity of the extracts of P. parnassica. From the roots of this species, seventeen compounds were subsequently isolated and identified. Amongst these, seven contained the characteristic cage-like terpenic skeleton that is found only in plants of the genus Paeonia. Two of the above products: 4-O-methylpaeoniflorin (1) and paeonidanin (2) are described for the first time as natural products. The structures of all compounds have been elucidated on the basis of their spectral data. © 2007 SAGE Publications Inc.
ER -