The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization.

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:2710170 469 Αναγνώσεις

Μονάδα:
Τμήμα Βιολογίας
Τίτλος:
The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization.
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC
consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological
conditions it forms amyloid fibrils in brain arteries of young adults. An ‘aggregation-prone’ pentapeptide
(47LQVVR51) was located within the HCC sequence using AmylPred, an ‘aggregation-prone’
peptide prediction algorithm developed in our lab. This peptide was synthesized and self-assembled
into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, Attenuated Total
Reflectance Fourier-Transform Spectroscopy and Congo red staining studies reveal. Thus, the
47-LQVVR-51 peptide seems to have an important role in HCC fibrillization.
Έτος δημοσίευσης:
2015
Συγγραφείς:
Paraskevi Tsiolaki
Stavros Hamodrakas
Vassiliki Iconomidou
Περιοδικό:
FEBS Letters
Εκδότης:
Wiley
Τόμος:
589
Αριθμός / τεύχος:
1
Σελίδες:
159-164
Λέξεις-κλειδιά:
Human cystatin C, Hereditary Cystatin C Amyloid Angiopathy, Alzheimer’s disease, 3D-domain swapping, ‘Aggregation-prone’ pentapeptide LQVVR, Amyloid fibrils
Κύρια θεματική κατηγορία:
Επιστήμες Υγείας
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.