Anatomic and hemodynamic identification of vulnerable vessel segments

Doctoral Dissertation uoadl:1305646 298 Read counter

Unit:
Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences
Deposit date:
2015-11-09
Year:
2015
Author:
Πάντος Ιωάννης
Dissertation committee:
Ευστάθιος Ευσταθόπουλος, Νικόλαος Κελέκης, Ηλίας Μπρόυντζος
Original Title:
Ανατομικός και αιμοδυναμικός προσδιορισμός ευάλωτων αγγειακών τμημάτων
Languages:
Greek
Translated title:
Anatomic and hemodynamic identification of vulnerable vessel segments
Summary:
The scope of this thesis is to study the anatomic features of coronary arteries
and the intracoronary hemodynamic conditions in order to identify specific
anatomic and rheological characteristics which predispose coronary arteries
vulnerable to thrombosis and myocardial infarction following atheromatic
coronary plaque disruption. In order to achieve these goals, the anatomic
structure of coronary arteries associated with myocardial infarction or stable
coronary artery disease were studied by a developed algorithm for three
dimensional reconstruction of coronary arteries from two dimensional images of
conventional coronary angiography. The study of intracoronary flow was achieved
by computational flow dynamics simulations at models of vulnerable and stable
coronary segments and it was focused at rheological parameters which are
associated to thrombosis. Results identified that there are specific anatomic
features of the coronary arteries which are associated to myocardial infarction
and which create local hemodynamic conditions which promote thrombosis
following the rupture of atheromatic coronary plaques.
Keywords:
Coronary artery disease, Atheromatosis, Thrombosis, Three dimensional reconstruction, Flow simulations
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
125
Number of pages:
107
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