Unit:
Τομέας ΚλινικοεργαστηριακόςLibrary of the School of Health Sciences
Author:
Φουντουλάκη-Παπαρίζου Λεοντίνη
Dissertation committee:
Τραυλού Ανθή, Πέρρος Γεώργιος, Πολίτου Μαριάννα
Original Title:
Ανίχνευση αντιερυθροκυτταρικών αντισωμάτων στην κύηση. Επιδημιολογικά δεδομένα στην Ελλάδα
Translated title:
Detection red blood cell antibodies in pregnancy. Epidimiological data in Greece
Summary:
AIM/OBJECTIVES:
To access the incidence and specificity of maternal red blood cells
alloimmunisation and its relevant clinical impact in Greece.
BACKGROUND:
The rate of alloimmunisation in pregnant women in Greece is unknown.
MATERIALS/METHODS:
We performed a 4-year study in two tertiary hospitals in Greece. Demographics,
transfusion and obstetric history were analysed. Maternal alloimmunisation was
detected with indirect anti-globulin test.
RESULTS:
We investigated 4368 pregnant women. Of which 3292 (75•37%) were Greek and 1076
(24•63%) were migrants. In 39 alloimmunised women, 41 alloantibodies were
detected (0•89%). The incidence of alloimmunisation was 0•66% (22/3292) in
Greeks and 1•76% (17/1076) in migrants (P=0•01). Anti-D was the most frequent
alloantibody (0•18%). Anti-D was more frequent in migrants; 5•76% compared to
0•56% in Greek RhD negative women (P=0•002). Other antibody specificities in
declining frequency rank were anti-K, anti-E, anti-Lea, anti-M, anti-c,
anti-Ce, anti-Jka, anti-Jkb and anti-C. Primiparae vs para >2 and past history
of blood transfusion were significantly associated with alloimmunisation during
pregnancy (P=0•0088, P<0•0001, respectively).
CONCLUSIONS:
Our results depict differences in the delivery of health care between migrants
and Greek women, as well as the heterogeneity in practices for the prevention
of haemolytic disease of foetus and newborn in Greece and highlight the need
for the implementation of nationwide guidelines.
Keywords:
Red blood cell antibodies, Haemolytic disease of fetus-newborn , Pregnancy, Maternal alloimmunisation, Greece
Number of references:
153
